TY - JOUR
T1 - The rs12594956 polymorphism in the NRF-2 gene is associated with top-level Spanish athlete's performance status
AU - Eynon, Nir
AU - Ruiz, Jonatan R.
AU - Bishop, David J.
AU - Santiago, Catalina
AU - Gómez-Gallego, Félix
AU - Lucia, Alejandro
AU - Birk, Ruth
N1 - Funding Information:
The present study was partially funded by the Spanish Ministry of Science and Innovation ( RYC-2010-05957 ) and, Fondo de Investigaciones Sanitarias (FIS, ref. # PS09/00194).
PY - 2013/3
Y1 - 2013/3
N2 - Objectives: To determine the association between the nuclear respiratory factor 2 (NRF-2) polymorphisms and elite athletic performance. Design: We compared the genotype and allele frequencies of the NRF-2 A/C (rs12594956), NRF-2 A/G (rs7181866), and NRF-2 C/T (rs8031031) polymorphisms between world-class endurance athletes (n=89), elite power-oriented athletes (n=38), and non-athletic controls (n=110) of the same Caucasian (Spanish) origin. Methods: Genomic DNA was extracted from peripheral EDTA-treated, anti-coagulated blood using a standard protocol. Genotyping was performed using polymerase chain reaction (PCR). Results: The frequency of the AA genotype of the NRF-2 A/C (rs12594956) polymorphism was significantly higher in endurance athletes compared with power athletes (p<0.01) and controls (p<0.01) (48% vs. 13% and 21%, respectively). The likelihood of having the AA (rs12594956) genotype was higher in elite endurance athletes compared with controls [odds ratio (OR): 3.536, 95% confidence interval (CI): 1.903-6.571] and elite power athletes (OR: 6.170, 95%CI: 2.206-17.253). Conclusions: Our results suggest that the NRF-2 A/C polymorphism might belong to a growing group of polymorphisms associated with endurance performance at the elite level. However, it is important to replicate these findings in other groups of elite athletes using larger sample sizes.
AB - Objectives: To determine the association between the nuclear respiratory factor 2 (NRF-2) polymorphisms and elite athletic performance. Design: We compared the genotype and allele frequencies of the NRF-2 A/C (rs12594956), NRF-2 A/G (rs7181866), and NRF-2 C/T (rs8031031) polymorphisms between world-class endurance athletes (n=89), elite power-oriented athletes (n=38), and non-athletic controls (n=110) of the same Caucasian (Spanish) origin. Methods: Genomic DNA was extracted from peripheral EDTA-treated, anti-coagulated blood using a standard protocol. Genotyping was performed using polymerase chain reaction (PCR). Results: The frequency of the AA genotype of the NRF-2 A/C (rs12594956) polymorphism was significantly higher in endurance athletes compared with power athletes (p<0.01) and controls (p<0.01) (48% vs. 13% and 21%, respectively). The likelihood of having the AA (rs12594956) genotype was higher in elite endurance athletes compared with controls [odds ratio (OR): 3.536, 95% confidence interval (CI): 1.903-6.571] and elite power athletes (OR: 6.170, 95%CI: 2.206-17.253). Conclusions: Our results suggest that the NRF-2 A/C polymorphism might belong to a growing group of polymorphisms associated with endurance performance at the elite level. However, it is important to replicate these findings in other groups of elite athletes using larger sample sizes.
KW - Exercise
KW - Genetics
KW - Polymorphism
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=84873522413&partnerID=8YFLogxK
U2 - 10.1016/j.jsams.2012.05.004
DO - 10.1016/j.jsams.2012.05.004
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C2 - 22749526
AN - SCOPUS:84873522413
SN - 1440-2440
VL - 16
SP - 135
EP - 139
JO - Journal of Science and Medicine in Sport
JF - Journal of Science and Medicine in Sport
IS - 2
ER -