TY - JOUR
T1 - The role of chromatin structure in cell migration
AU - Gerlitz, Gabi
AU - Bustin, Michael
N1 - Funding Information:
We thank Edina Rosta (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD USA) and Nicolae Viorel Buchete (School of Physics, University College Dublin, Dublin, Ireland) for helpful discussions and Yosef Gruenbaum (Department of Genetics, Alexander Silberman Institute of Life Science, Hebrew University of Jerusalem, Jerusalem 91904, Israel) for comments on the manuscript. This work was supported by the Intramural Research Program of the National Institutes of Health, Center for Cancer Research, National Cancer Institute.
PY - 2011/1
Y1 - 2011/1
N2 - Chromatin dynamics play a major role in regulating genetic processes. Now, accumulating data suggest that chromatin structure may also affect the mechanical properties of the nucleus and cell migration. Global chromatin organization appears to modulate the shape, the size and the stiffness of the nucleus. Directed-cell migration, which often requires nuclear reshaping to allow passage of cells through narrow openings, is dependent not only on changes in cytoskeletal elements but also on global chromatin condensation. Conceivably, during cell migration a physical link between the chromatin and the cytoskeleton facilitates coordinated structural changes in these two components. Thus, in addition to regulating genetic processes, we suggest that alterations in chromatin structure could facilitate cellular reorganizations necessary for efficient migration.
AB - Chromatin dynamics play a major role in regulating genetic processes. Now, accumulating data suggest that chromatin structure may also affect the mechanical properties of the nucleus and cell migration. Global chromatin organization appears to modulate the shape, the size and the stiffness of the nucleus. Directed-cell migration, which often requires nuclear reshaping to allow passage of cells through narrow openings, is dependent not only on changes in cytoskeletal elements but also on global chromatin condensation. Conceivably, during cell migration a physical link between the chromatin and the cytoskeleton facilitates coordinated structural changes in these two components. Thus, in addition to regulating genetic processes, we suggest that alterations in chromatin structure could facilitate cellular reorganizations necessary for efficient migration.
UR - http://www.scopus.com/inward/record.url?scp=78650527018&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2010.09.002
DO - 10.1016/j.tcb.2010.09.002
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C2 - 20951589
AN - SCOPUS:78650527018
SN - 0962-8924
VL - 21
SP - 6
EP - 11
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 1
ER -