The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

Aaron Hoffman; Ehud Grossman; K. Peter Öhman; Eric Marks; Harry R. Keiser

doi:10.1093/ajh/3.10.789

The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

Aaron Hoffman, Ehud Grossman, K. Peter Öhman, Eric Marks, Harry R. Keiser

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.

Original language	English
Pages (from-to)	789-791
Number of pages	3
Journal	American Journal of Hypertension
Volume	3
Issue number	10
DOIs	https://doi.org/10.1093/ajh/3.10.789
State	Published - Oct 1990
Externally published	Yes

Keywords

Blood flow
Endothelin
Vascular resistance

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10.1093/ajh/3.10.789

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title = "The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds",

abstract = "The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.",

keywords = "Blood flow, Endothelin, Vascular resistance",

author = "Aaron Hoffman and Ehud Grossman and {\"O}hman, \{K. Peter\} and Eric Marks and Keiser, \{Harry R.\}",

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T1 - The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

AU - Hoffman, Aaron

AU - Grossman, Ehud

AU - Öhman, K. Peter

AU - Marks, Eric

AU - Keiser, Harry R.

PY - 1990/10

Y1 - 1990/10

N2 - The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.

AB - The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.

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KW - Endothelin

KW - Vascular resistance

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JF - American Journal of Hypertension

IS - 10

ER -

The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

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