TY - JOUR
T1 - The influence of meal composition on plasma serotonin and norepinephrine concentrations
AU - Blum, I.
AU - Vered, Y.
AU - Graff, E.
AU - Grosskopf, Y.
AU - Don, R.
AU - Harsat, A.
AU - Raz, O.
PY - 1992/2
Y1 - 1992/2
N2 - Reports concerning changes in plasma neurotransmitter values that result from dietary manipulations have not been published so far. The influence of various meal composition on platelet-poor plasma (PPP) serotonin (5-HT) and norepinephrine (NE) levels was investigated. Healthy volunteers were subjected to three test meals: a carbohydrate-rich meal (86% carbohydrates), a protein-rich meal (70% protein), and a fat-rich meal (92% fat). After a carbohydrate-rich meal, PPP 5-HT values increased significantly (4.47-fold, P < .02), whereas a smaller increase (1.66-fold, P = NS) was observed after a fat-rich meal. These effects on PPP 5-HT values could be correlated with insulin plasma levels. A protein-rich meal significantly reduced (P = 0.0011) PPP 5-HT to 28% of initial values, despite an increase in plasma insulin levels. This study has shown that (1) changes in meal compositions influence PPP 5-HT and, to a lesser extent, NE values; (2) the resulting changes in PPP 5-HT levels parallel those reported for brain neurotransmitters; and (3) these results seem to indicate that PPP 5-HT levels may be a model for brain synthesis and release of 5-HT.
AB - Reports concerning changes in plasma neurotransmitter values that result from dietary manipulations have not been published so far. The influence of various meal composition on platelet-poor plasma (PPP) serotonin (5-HT) and norepinephrine (NE) levels was investigated. Healthy volunteers were subjected to three test meals: a carbohydrate-rich meal (86% carbohydrates), a protein-rich meal (70% protein), and a fat-rich meal (92% fat). After a carbohydrate-rich meal, PPP 5-HT values increased significantly (4.47-fold, P < .02), whereas a smaller increase (1.66-fold, P = NS) was observed after a fat-rich meal. These effects on PPP 5-HT values could be correlated with insulin plasma levels. A protein-rich meal significantly reduced (P = 0.0011) PPP 5-HT to 28% of initial values, despite an increase in plasma insulin levels. This study has shown that (1) changes in meal compositions influence PPP 5-HT and, to a lesser extent, NE values; (2) the resulting changes in PPP 5-HT levels parallel those reported for brain neurotransmitters; and (3) these results seem to indicate that PPP 5-HT levels may be a model for brain synthesis and release of 5-HT.
UR - http://www.scopus.com/inward/record.url?scp=0026502302&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(92)90141-V
DO - 10.1016/0026-0495(92)90141-V
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C2 - 1736036
AN - SCOPUS:0026502302
SN - 0026-0495
VL - 41
SP - 137
EP - 140
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 2
ER -