The influence of cefepime on opsonophagocytosis of bacteria

G. Raponi, N. Keller, M. Rozenberg-Arska, I. M. Hoepelman, J. Verhoef

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The effect of subminimal inhibitory concentrations (sub-MICs) of a semi-synthetic β-lactam antibiotic, cefepime (BMY 28142), was studied on the opsonophagocytosis by human polymorphonuclear leukocytes (PNMs) of strains of Escherichia coli, Klebsiella oxytoca and Staphylococcus aureus. Cefepime-treated Gram-negative bacteria were not better phagocytosed by PMNs; however the uptake of one of three S. aureus strains was enhanced. The effect of cefepime on the uptake of strains of E. coli was compared to that of two other β-lactam antibiotics, mecillinam and ceftriaxone. Exposure of E. coli to sub-MICs of mecillinam and ceftriaxone enhanced phagocytosis by PMNs.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalDrugs under Experimental and Clinical Research
Issue number4
StatePublished - 1989
Externally publishedYes


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