The effect of post-resistance exercise amino acids on plasma MCP-1 and CCR2 expression

Adam J. Wells, Jay R. Hoffman, Adam R. Jajtner, Alyssa N. Varanoske, David D. Church, Adam M. Gonzalez, Jeremy R. Townsend, Carleigh H. Boone, Kayla M. Baker, Kyle S. Beyer, Gerald T. Mangine, Leonardo P. Oliveira, David H. Fukuda, Jeffrey R. Stout

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The recruitment and infiltration of classical monocytes into damaged muscle is critical for optimal tissue remodeling. This study examined the effects of an amino acid supplement on classical monocyte recruitment following an acute bout of lower body resistance exercise. Ten resistance-trained men (24.7 ± 3.4 years; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) ingested supplement (SUPP) or placebo (PL) immediately post-exercise in a randomized, cross-over design. Blood samples were obtained at baseline (BL), immediately (IP), 30-min (30P), 1-h (1H), 2-h (2H), and 5-h (5H) post-exercise to assess plasma concentrations of monocyte chemoattractant protein 1 (MCP-1), myoglobin, cortisol and insulin concentrations; and expressions of C-C chemokine receptor-2 (CCR2), and macrophage-1 antigen (CD11b) on classical monocytes. Magnitude-based inferences were used to provide inferences on the true effects of SUPP compared to PL. Changes in myoglobin, cortisol, and insulin concentrations were similar between treatments. Compared to PL, plasma MCP-1 was “very likely greater” (98.1% likelihood effect) in SUPP at 2H. CCR2 expression was “likely greater” at IP (84.9% likelihood effect), “likely greater” at 1H (87.7% likelihood effect), “very likely greater” at 2H (97.0% likelihood effect), and “likely greater” at 5H (90.1% likelihood effect) in SUPP, compared to PL. Ingestion of SUPP did not influence CD11b expression. Ingestion of an amino acid supplement immediately post-exercise appears to help maintain plasma MCP-1 concentrations and augment CCR2 expression in resistance trained men.

Original languageEnglish
Article number409
Issue number7
StatePublished - 2 Jul 2016
Externally publishedYes


  • C-C chemokine receptor 2 (CCR2)
  • Inflammation
  • Macrophage-1 antigen (cluster of differentiation 11b (CD11b))
  • Monocyte chemoattractant protein 1 (MCP-1)


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