TY - JOUR
T1 - The effect of photochemotherapy with 4,4',6 trimethylangelicin on murine cutaneous immune cells
AU - Alcalay, J.
AU - Dall'Acqua, F.
AU - Kripke, M. L.
PY - 1990
Y1 - 1990
N2 - The effect of photochemotherapy with 4,4',6 trimethylangelicin (TMA), a new monofunctional furocoumarin with a high antiproliferative activity, was studied on murine dendritic epidermal cells. Female mice (C3H/HeN[MTV-]) were treated topically with the drug three times a week for 4 consecutive weeks followed each time by I J/cm2 of UVA radiation. At the end of the treatment almost total depletion of ATPase+, Ia+ and Thy-I+ dendritic epidermal cells was observed, associated with marked hyperpigmentation but no gross or microscopic phototoxicity. Although 4,4',6 TMA is not phototoxic in mice, it affects the cutaneous immune cells.
AB - The effect of photochemotherapy with 4,4',6 trimethylangelicin (TMA), a new monofunctional furocoumarin with a high antiproliferative activity, was studied on murine dendritic epidermal cells. Female mice (C3H/HeN[MTV-]) were treated topically with the drug three times a week for 4 consecutive weeks followed each time by I J/cm2 of UVA radiation. At the end of the treatment almost total depletion of ATPase+, Ia+ and Thy-I+ dendritic epidermal cells was observed, associated with marked hyperpigmentation but no gross or microscopic phototoxicity. Although 4,4',6 TMA is not phototoxic in mice, it affects the cutaneous immune cells.
UR - http://www.scopus.com/inward/record.url?scp=0025138470&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2133.1990.tb08233.x
DO - 10.1111/j.1365-2133.1990.tb08233.x
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C2 - 2297508
AN - SCOPUS:0025138470
SN - 0007-0963
VL - 122
SP - 9
EP - 14
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 1
ER -