Abstract
Background: Heartburn (HB) and acid reflux (RF) in the non pregnant population can cause nausea and vomiting; therefore, it is plausible that in women with nausea and vomiting of pregnancy (NVP), HB/RF may increase the severitv of symptoms. Objective: To determine whether HB/RF during pregnancy contribute to increased severity of NVP. Methods: A prospectively collected cohort of women who were experiencing NVP and HB, RF or both (n=194) was studied. The Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scale and its Well-being scale was used to compare the severity of the study cohort's symptoms. This cohort was compared with a group of women experiencing NVP but no HB/RF (n=188). Multiple linear regression was used to control for the effects of confounding factors. Results: Women with HB/RF reported higher PUQE scores (9.6±2.6) compared with controls (8.9±2.6) (P=0.02). Similarly, Well-being scores for women experiencing HB/RF were lower (4.3±2.1) compared with controls (4.9± 2.0) (P=0.01). Multiple linear regression analysis demonstrated that increased PUQE scores (P=0.003) and decreased Well-being scores (P=0.005) were due to the presence of HB/RF as opposed to confounding factors such as pre-existing gastrointestinal conditions/ symptoms, hyperemesis gravidarum in previous pregnancies and comorbidities. Conclusion: The present cohort study is the first to demonstrate that HB/ RF are associated with increased severity of NVP. Managing HB/RF may improve the severity of NVP.
Original language | English |
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Pages (from-to) | 270-272 |
Number of pages | 3 |
Journal | Canadian Journal of Gastroenterology |
Volume | 23 |
Issue number | 4 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Keywords
- Acid reflux
- Heartburn
- Nausea and vomiting of pregnancy (NVPJ)
- PUQE