TY - JOUR
T1 - The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight
T2 - A double-blind, randomized control trial
AU - Mangine, Gerald T.
AU - Gonzalez, Adam M.
AU - Wells, Adam J.
AU - McCormack, William P.
AU - Fragala, Maren S.
AU - Stout, Jeffrey R.
AU - Hoffman, Jay R.
N1 - Funding Information:
The authors would like to thank a dedicated group of volunteers. This study was supported by a grant from Chemi Nutra, White Bear Lake, MN.
PY - 2012
Y1 - 2012
N2 - Background: A dietary supplement containing a blend of 170mg of N-oleyl-phosphatidylethanolamine (NOPE) and 100mg of epigallocatechin-3-gallate (EGCG) has been shown to improve compliance to low caloric diets. Considering the cost of dietary ingredients, many manufacturers attempt to determine the lowest efficacious dose. Thus, the purpose of this study was to evaluate the efficacy of 8-weeks of supplementation with a daily intake of 120mg of NOPE and 105mg of EGCG in conjunction with a low caloric diet and regular, moderate exercise on dietary compliance in healthy, overweight adults. An additional purpose was to examine the effect of this supplement/diet/exercise paradigm on changes in body composition, sensation of appetite, mood and severity of binge eating. Methods. Fifty healthy, overweight (BMI>25mkg2) men (15) and women (35) (SUP; n=25; 32.713.75 y; BMI=33.46.2; PLA; n=25, 34.312.7years; BMI=33.26.8) were recruited for a double-blind, placebo controlled study. Each volunteer was randomly assigned to either the supplement (SUP; n=25) or placebo group (PLA; n=25). Based upon a self-reported 3-day dietary recall all volunteers were recommended a 500kcal or 30% (maximum of 1000kcal) reduction in caloric intake. Volunteers were also encouraged to exercise 30minutes per day, three times per week. Results: Subjects in SUP were significantly more compliant (x 2=3.86, p=0.049) in maintaining a low caloric diet at week 4, but this was not able to be maintained through the 8-week study. In addition, a significant difference in mood, feelings of fatigue and confusion were noted between the groups at week 4, but again not maintained by week 8 where only feelings of tension were improved. No differences between groups (p>0.05) were observed for body mass, body composition, feelings of hunger, and binge eating after eight weeks. Conclusion: Supplementing with a combination of 120mg of NOPE and 105mg of EGCG does appear to enhance compliance to a low caloric diet and improve mood for 4 -weeks, but loses its effectiveness by week 8.
AB - Background: A dietary supplement containing a blend of 170mg of N-oleyl-phosphatidylethanolamine (NOPE) and 100mg of epigallocatechin-3-gallate (EGCG) has been shown to improve compliance to low caloric diets. Considering the cost of dietary ingredients, many manufacturers attempt to determine the lowest efficacious dose. Thus, the purpose of this study was to evaluate the efficacy of 8-weeks of supplementation with a daily intake of 120mg of NOPE and 105mg of EGCG in conjunction with a low caloric diet and regular, moderate exercise on dietary compliance in healthy, overweight adults. An additional purpose was to examine the effect of this supplement/diet/exercise paradigm on changes in body composition, sensation of appetite, mood and severity of binge eating. Methods. Fifty healthy, overweight (BMI>25mkg2) men (15) and women (35) (SUP; n=25; 32.713.75 y; BMI=33.46.2; PLA; n=25, 34.312.7years; BMI=33.26.8) were recruited for a double-blind, placebo controlled study. Each volunteer was randomly assigned to either the supplement (SUP; n=25) or placebo group (PLA; n=25). Based upon a self-reported 3-day dietary recall all volunteers were recommended a 500kcal or 30% (maximum of 1000kcal) reduction in caloric intake. Volunteers were also encouraged to exercise 30minutes per day, three times per week. Results: Subjects in SUP were significantly more compliant (x 2=3.86, p=0.049) in maintaining a low caloric diet at week 4, but this was not able to be maintained through the 8-week study. In addition, a significant difference in mood, feelings of fatigue and confusion were noted between the groups at week 4, but again not maintained by week 8 where only feelings of tension were improved. No differences between groups (p>0.05) were observed for body mass, body composition, feelings of hunger, and binge eating after eight weeks. Conclusion: Supplementing with a combination of 120mg of NOPE and 105mg of EGCG does appear to enhance compliance to a low caloric diet and improve mood for 4 -weeks, but loses its effectiveness by week 8.
KW - Appetite
KW - Dietary Adherence
KW - Green Tea Extract
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84866914839&partnerID=8YFLogxK
U2 - 10.1186/1476-511X-11-127
DO - 10.1186/1476-511X-11-127
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C2 - 23033919
AN - SCOPUS:84866914839
SN - 1476-511X
VL - 11
JO - Lipids in Health and Disease
JF - Lipids in Health and Disease
M1 - 127
ER -