TY - JOUR
T1 - The complex role of SIRT6 in carcinogenesis
AU - Lerrer, Batia
AU - Gertler, Asaf A.
AU - Cohen, Haim Y.
N1 - Publisher Copyright:
© The Author 2015. Published by Oxford University Press. All rights reserved.
PY - 2015/9/8
Y1 - 2015/9/8
N2 - SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.
AB - SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.
UR - http://www.scopus.com/inward/record.url?scp=84962026722&partnerID=8YFLogxK
U2 - 10.1093/carcin/bgv167
DO - 10.1093/carcin/bgv167
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C2 - 26717993
AN - SCOPUS:84962026722
SN - 0143-3334
VL - 37
SP - 108
EP - 118
JO - Carcinogenesis
JF - Carcinogenesis
IS - 2
ER -