The complex role of SIRT6 in carcinogenesis

Batia Lerrer, Asaf A. Gertler, Haim Y. Cohen

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.

Original languageEnglish
Pages (from-to)108-118
Number of pages11
Issue number2
StatePublished - 8 Sep 2015
Externally publishedYes


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