TY - JOUR
T1 - The changing face of neural stem cell therapy in neurologic diseases
AU - Einstein, Ofira
AU - Ben-Hur, Tamir
PY - 2008/4
Y1 - 2008/4
N2 - New insights into the biology of neural stem cells (NSCs) have raised expectations for their use in the treatment of neurologic diseases. Originally, NSC transplantation was proposed as a means of replacing cells in central nervous system diseases that result in cell loss. However, recent data regarding their beneficial effects in various animal models of neurologic diseases indicate that transplanted NSCs may also attenuate deleterious inflammation, protect the central nervous system from degeneration, and enhance endogenous recovery processes. Herein, we review recent developments and future prospects of NSC therapy in neurologic diseases.
AB - New insights into the biology of neural stem cells (NSCs) have raised expectations for their use in the treatment of neurologic diseases. Originally, NSC transplantation was proposed as a means of replacing cells in central nervous system diseases that result in cell loss. However, recent data regarding their beneficial effects in various animal models of neurologic diseases indicate that transplanted NSCs may also attenuate deleterious inflammation, protect the central nervous system from degeneration, and enhance endogenous recovery processes. Herein, we review recent developments and future prospects of NSC therapy in neurologic diseases.
UR - http://www.scopus.com/inward/record.url?scp=42249086829&partnerID=8YFLogxK
U2 - 10.1001/archneur.65.4.452
DO - 10.1001/archneur.65.4.452
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C2 - 18413466
AN - SCOPUS:42249086829
SN - 0003-9942
VL - 65
SP - 452
EP - 456
JO - Archives of Neurology
JF - Archives of Neurology
IS - 4
ER -