The case for strategic international alliances to harness nutritional genomics for public and personal health

Jim Kaput; Jose M. Ordovas; Lynnette Ferguson; Ben van Ommen; Raymond L. Rodriguez; Lindsay Allen; Bruce N. Ames; Kevin Dawson; Bruce German; Ronald Krauss; Wasyl Malyj; Michael C. Archer; Stephen Barnes; Amelia Bortholomew; Ruth Birk; Peter van Bladeren; Kent J. Bradford; Kenneth H. Brown; Rosane Caetano; David Castle; Ruth Chadwick; Stephen Clarke; Karine Clemént; Craig A. Cooney; Dolores Corella; Ivana Beatrice Manica da Cruz; Hannelore Daniel; Troy Duster; Sven O.E. Ebbesson; Ruan Elliott; Susan Fairweather-Tait; Jim Felton; Michael Fenech; John W. Finley; Nancy Fogg-Johnson; Rosalynn Gill-Garrison; Michael J. Gibney; Peter J. Gillies; Jan Ake Gustafsson; John L. Hartman IV; Lin He; Jae Kwan Hwang; Jean Philippe Jais; Yangsoo Jang; Hans Joost; Claudine Junien; Mitchell Kanter; Warren A. Kibbe; Berthold Koletzko; Bruce R. Korf; Kenneth Kornman; David W. Krempin; Dominique Langin; Dennis R. Lauren; Jong Ho Lee; Gilbert A. Leveille; Su Ju Lin; John Mathers; Michael Mayne; Warren McNabb; John A. Milner; Peter Morgan; Michael Muller; Yuri Nikolsky; Frans van der Ouderaa; Taesun Park; Norma Pensel; Francisco Perez-Jimenez; Kaisa Poutanen; Matthew Roberts; Wim H.M. Saris; Gertrud Schuster; Andrew N. Shelling; Artemis P. Simopoulos; Sue Southon; E. Shyong Tai; Bradford Towne; Paul Trayhurn; Ricardo Uauy; Willard J. Visek; Craig Warden; Rick Weiss; John Wiencke; Jack Winkler; George L. Wolff; Xi Zhao-Wilson; Jean Daniel Zucker

doi:10.1079/BJN20051585

The case for strategic international alliances to harness nutritional genomics for public and personal health

Jim Kaput, Jose M. Ordovas, Lynnette Ferguson, Ben van Ommen, Raymond L. Rodriguez, Lindsay Allen, Bruce N. Ames, Kevin Dawson, Bruce German, Ronald Krauss, Wasyl Malyj, Michael C. Archer, Stephen Barnes, Amelia Bortholomew, Ruth Birk, Peter van Bladeren, Kent J. Bradford, Kenneth H. Brown, Rosane Caetano, David CastleRuth Chadwick, Stephen Clarke, Karine Clemént, Craig A. Cooney, Dolores Corella, Ivana Beatrice Manica da Cruz, Hannelore Daniel, Troy Duster, Sven O.E. Ebbesson, Ruan Elliott, Susan Fairweather-Tait, Jim Felton, Michael Fenech, John W. Finley, Nancy Fogg-Johnson, Rosalynn Gill-Garrison, Michael J. Gibney, Peter J. Gillies, Jan Ake Gustafsson, John L. Hartman IV, Lin He, Jae Kwan Hwang, Jean Philippe Jais, Yangsoo Jang, Hans Joost, Claudine Junien, Mitchell Kanter, Warren A. Kibbe, Berthold Koletzko, Bruce R. Korf, Kenneth Kornman, David W. Krempin, Dominique Langin, Dennis R. Lauren, Jong Ho Lee, Gilbert A. Leveille, Su Ju Lin, John Mathers, Michael Mayne, Warren McNabb, John A. Milner, Peter Morgan, Michael Muller, Yuri Nikolsky, Frans van der Ouderaa, Taesun Park, Norma Pensel, Francisco Perez-Jimenez, Kaisa Poutanen, Matthew Roberts, Wim H.M. Saris, Gertrud Schuster, Andrew N. Shelling, Artemis P. Simopoulos, Sue Southon, E. Shyong Tai, Bradford Towne, Paul Trayhurn, Ricardo Uauy, Willard J. Visek, Craig Warden, Rick Weiss, John Wiencke, Jack Winkler, George L. Wolff, Xi Zhao-Wilson, Jean Daniel Zucker

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Original language	English
Pages (from-to)	623-632
Number of pages	10
Journal	British Journal of Nutrition
Volume	94
Issue number	5
DOIs	https://doi.org/10.1079/BJN20051585
State	Published - Nov 2005
Externally published	Yes

Keywords

Gene-nutrient interactions
Health diaparities
Nutrigenomics
Strategic international alliances

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10.1079/BJN20051585

Cite this

Kaput, J., Ordovas, J. M., Ferguson, L., van Ommen, B., Rodriguez, R. L., Allen, L., Ames, B. N., Dawson, K., German, B., Krauss, R., Malyj, W., Archer, M. C., Barnes, S., Bortholomew, A., Birk, R., van Bladeren, P., Bradford, K. J., Brown, K. H., Caetano, R., ... Zucker, J. D. (2005). The case for strategic international alliances to harness nutritional genomics for public and personal health. British Journal of Nutrition, 94(5), 623-632. https://doi.org/10.1079/BJN20051585

@article{543f0b535b3f4a9587bce00ac0b7eb2f,

title = "The case for strategic international alliances to harness nutritional genomics for public and personal health",

abstract = "Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.",

keywords = "Gene-nutrient interactions, Health diaparities, Nutrigenomics, Strategic international alliances",

author = "Jim Kaput and Ordovas, {Jose M.} and Lynnette Ferguson and {van Ommen}, Ben and Rodriguez, {Raymond L.} and Lindsay Allen and Ames, {Bruce N.} and Kevin Dawson and Bruce German and Ronald Krauss and Wasyl Malyj and Archer, {Michael C.} and Stephen Barnes and Amelia Bortholomew and Ruth Birk and {van Bladeren}, Peter and Bradford, {Kent J.} and Brown, {Kenneth H.} and Rosane Caetano and David Castle and Ruth Chadwick and Stephen Clarke and Karine Clem{\'e}nt and Cooney, {Craig A.} and Dolores Corella and {da Cruz}, {Ivana Beatrice Manica} and Hannelore Daniel and Troy Duster and Ebbesson, {Sven O.E.} and Ruan Elliott and Susan Fairweather-Tait and Jim Felton and Michael Fenech and Finley, {John W.} and Nancy Fogg-Johnson and Rosalynn Gill-Garrison and Gibney, {Michael J.} and Gillies, {Peter J.} and Gustafsson, {Jan Ake} and {Hartman IV}, {John L.} and Lin He and Hwang, {Jae Kwan} and Jais, {Jean Philippe} and Yangsoo Jang and Hans Joost and Claudine Junien and Mitchell Kanter and Kibbe, {Warren A.} and Berthold Koletzko and Korf, {Bruce R.} and Kenneth Kornman and Krempin, {David W.} and Dominique Langin and Lauren, {Dennis R.} and Lee, {Jong Ho} and Leveille, {Gilbert A.} and Lin, {Su Ju} and John Mathers and Michael Mayne and Warren McNabb and Milner, {John A.} and Peter Morgan and Michael Muller and Yuri Nikolsky and {van der Ouderaa}, Frans and Taesun Park and Norma Pensel and Francisco Perez-Jimenez and Kaisa Poutanen and Matthew Roberts and Saris, {Wim H.M.} and Gertrud Schuster and Shelling, {Andrew N.} and Simopoulos, {Artemis P.} and Sue Southon and {Shyong Tai}, E. and Bradford Towne and Paul Trayhurn and Ricardo Uauy and Visek, {Willard J.} and Craig Warden and Rick Weiss and John Wiencke and Jack Winkler and Wolff, {George L.} and Xi Zhao-Wilson and Zucker, {Jean Daniel}",

note = "Funding Information: Interdisciplinary research is being fostered within institutions (Cech & Rubin, 2004) and through national and international collaborations. Four of these multi-institutional and national initiatives are examples of collaborative efforts for nutritional genomics research. The Pharmacogenetics and Pharmacogenomics Knowledge Base, also known as PharmGKB, developed by Stanford University, is funded by the National Institutes of Health and is part of a nationwide collaborative research consortium called the Pharmacogenetics Research Network (National Institute of General Medical Services, 2005; Pharmacogenetics and Pharmacogenomics Knowledge Base, 2005). PharmGKB is building a knowledge base with accurate and detailed definitions of genotypes and phenotypes involved in individual responses to different medications. Data are generated by the US National Institutes of Health-funded projects in twelve individual laboratories. Funding Information: Many of the authors of the present paper have already contributed significantly to the field of nutrigenomics, our current understanding of nutrient–gene interactions, and/or the effects of diet on health. It was not possible to reference all of these contributions in the paper. Although many contributed to this paper, primary support was obtained from the National Center for Minority Health and Health Disparities Center of Excellence in Nutritional Genomics, Grant MD 00222; from the New Zealand Foundation for Research Science and Technology Nutrigenomics New Zealand (8677 NTGN CRFO); National Institutes of Health/NHLBI grant HL54776, contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service; and from the European Union, Eu FP6 NoE Grant, Contract No. CT2004-505944.",

year = "2005",

month = nov,

doi = "10.1079/BJN20051585",

language = "אנגלית",

volume = "94",

pages = "623--632",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "5",

}

Kaput, J, Ordovas, JM, Ferguson, L, van Ommen, B, Rodriguez, RL, Allen, L, Ames, BN, Dawson, K, German, B, Krauss, R, Malyj, W, Archer, MC, Barnes, S, Bortholomew, A, Birk, R, van Bladeren, P, Bradford, KJ, Brown, KH, Caetano, R, Castle, D, Chadwick, R, Clarke, S, Clemént, K, Cooney, CA, Corella, D, da Cruz, IBM, Daniel, H, Duster, T, Ebbesson, SOE, Elliott, R, Fairweather-Tait, S, Felton, J, Fenech, M, Finley, JW, Fogg-Johnson, N, Gill-Garrison, R, Gibney, MJ, Gillies, PJ, Gustafsson, JA, Hartman IV, JL, He, L, Hwang, JK, Jais, JP, Jang, Y, Joost, H, Junien, C, Kanter, M, Kibbe, WA, Koletzko, B, Korf, BR, Kornman, K, Krempin, DW, Langin, D, Lauren, DR, Lee, JH, Leveille, GA, Lin, SJ, Mathers, J, Mayne, M, McNabb, W, Milner, JA, Morgan, P, Muller, M, Nikolsky, Y, van der Ouderaa, F, Park, T, Pensel, N, Perez-Jimenez, F, Poutanen, K, Roberts, M, Saris, WHM, Schuster, G, Shelling, AN, Simopoulos, AP, Southon, S, Shyong Tai, E, Towne, B, Trayhurn, P, Uauy, R, Visek, WJ, Warden, C, Weiss, R, Wiencke, J, Winkler, J, Wolff, GL, Zhao-Wilson, X & Zucker, JD 2005, 'The case for strategic international alliances to harness nutritional genomics for public and personal health', British Journal of Nutrition, vol. 94, no. 5, pp. 623-632. https://doi.org/10.1079/BJN20051585

TY - JOUR

T1 - The case for strategic international alliances to harness nutritional genomics for public and personal health

AU - Kaput, Jim

AU - Ordovas, Jose M.

AU - Ferguson, Lynnette

AU - van Ommen, Ben

AU - Rodriguez, Raymond L.

AU - Allen, Lindsay

AU - Ames, Bruce N.

AU - Dawson, Kevin

AU - German, Bruce

AU - Krauss, Ronald

AU - Malyj, Wasyl

AU - Archer, Michael C.

AU - Barnes, Stephen

AU - Bortholomew, Amelia

AU - Birk, Ruth

AU - van Bladeren, Peter

AU - Bradford, Kent J.

AU - Brown, Kenneth H.

AU - Caetano, Rosane

AU - Castle, David

AU - Chadwick, Ruth

AU - Clarke, Stephen

AU - Clemént, Karine

AU - Cooney, Craig A.

AU - Corella, Dolores

AU - da Cruz, Ivana Beatrice Manica

AU - Daniel, Hannelore

AU - Duster, Troy

AU - Ebbesson, Sven O.E.

AU - Elliott, Ruan

AU - Fairweather-Tait, Susan

AU - Felton, Jim

AU - Fenech, Michael

AU - Finley, John W.

AU - Fogg-Johnson, Nancy

AU - Gill-Garrison, Rosalynn

AU - Gibney, Michael J.

AU - Gillies, Peter J.

AU - Gustafsson, Jan Ake

AU - Hartman IV, John L.

AU - He, Lin

AU - Hwang, Jae Kwan

AU - Jais, Jean Philippe

AU - Jang, Yangsoo

AU - Joost, Hans

AU - Junien, Claudine

AU - Kanter, Mitchell

AU - Kibbe, Warren A.

AU - Koletzko, Berthold

AU - Korf, Bruce R.

AU - Kornman, Kenneth

AU - Krempin, David W.

AU - Langin, Dominique

AU - Lauren, Dennis R.

AU - Lee, Jong Ho

AU - Leveille, Gilbert A.

AU - Lin, Su Ju

AU - Mathers, John

AU - Mayne, Michael

AU - McNabb, Warren

AU - Milner, John A.

AU - Morgan, Peter

AU - Muller, Michael

AU - Nikolsky, Yuri

AU - van der Ouderaa, Frans

AU - Park, Taesun

AU - Pensel, Norma

AU - Perez-Jimenez, Francisco

AU - Poutanen, Kaisa

AU - Roberts, Matthew

AU - Saris, Wim H.M.

AU - Schuster, Gertrud

AU - Shelling, Andrew N.

AU - Simopoulos, Artemis P.

AU - Southon, Sue

AU - Shyong Tai, E.

AU - Towne, Bradford

AU - Trayhurn, Paul

AU - Uauy, Ricardo

AU - Visek, Willard J.

AU - Warden, Craig

AU - Weiss, Rick

AU - Wiencke, John

AU - Winkler, Jack

AU - Wolff, George L.

AU - Zhao-Wilson, Xi

AU - Zucker, Jean Daniel

N1 - Funding Information: Interdisciplinary research is being fostered within institutions (Cech & Rubin, 2004) and through national and international collaborations. Four of these multi-institutional and national initiatives are examples of collaborative efforts for nutritional genomics research. The Pharmacogenetics and Pharmacogenomics Knowledge Base, also known as PharmGKB, developed by Stanford University, is funded by the National Institutes of Health and is part of a nationwide collaborative research consortium called the Pharmacogenetics Research Network (National Institute of General Medical Services, 2005; Pharmacogenetics and Pharmacogenomics Knowledge Base, 2005). PharmGKB is building a knowledge base with accurate and detailed definitions of genotypes and phenotypes involved in individual responses to different medications. Data are generated by the US National Institutes of Health-funded projects in twelve individual laboratories. Funding Information: Many of the authors of the present paper have already contributed significantly to the field of nutrigenomics, our current understanding of nutrient–gene interactions, and/or the effects of diet on health. It was not possible to reference all of these contributions in the paper. Although many contributed to this paper, primary support was obtained from the National Center for Minority Health and Health Disparities Center of Excellence in Nutritional Genomics, Grant MD 00222; from the New Zealand Foundation for Research Science and Technology Nutrigenomics New Zealand (8677 NTGN CRFO); National Institutes of Health/NHLBI grant HL54776, contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service; and from the European Union, Eu FP6 NoE Grant, Contract No. CT2004-505944.

PY - 2005/11

Y1 - 2005/11

N2 - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

AB - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

KW - Gene-nutrient interactions

KW - Health diaparities

KW - Nutrigenomics

KW - Strategic international alliances

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C2 - 16277761

AN - SCOPUS:27944473261

SN - 0007-1145

VL - 94

SP - 623

EP - 632

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 5

ER -

The case for strategic international alliances to harness nutritional genomics for public and personal health

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