Teratogenicity of cyproheptadine in pregnant rats

D. Weinstein, A. Ornoy, Z. Ben-Zur, Y. Pfeifer, G. H. Sulman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Three groups of pregnant rats received respectively 0.5, 2.5 and 5 mg/kg/day cyproheptadine subcutaneously and a control group received 0.2 ml/day of the solvent normal saline. Higher doses were toxic to pregnant rats. There was no significant difference in birth rate, fetal resorption rate and malformation rate between the 4 groups. There was no significant difference between average weights, average fetal placental weights and male/female ratio in the experimental and control fetuses. It is concluded that cyproheptadine has no teratogenic effects in rat.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalArchives Internationales de Pharmacodynamie et de Therapie
Issue number2
StatePublished - 1975
Externally publishedYes


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