Abstract
Three groups of pregnant rats received respectively 0.5, 2.5 and 5 mg/kg/day cyproheptadine subcutaneously and a control group received 0.2 ml/day of the solvent normal saline. Higher doses were toxic to pregnant rats. There was no significant difference in birth rate, fetal resorption rate and malformation rate between the 4 groups. There was no significant difference between average weights, average fetal placental weights and male/female ratio in the experimental and control fetuses. It is concluded that cyproheptadine has no teratogenic effects in rat.
| Original language | English |
|---|---|
| Pages (from-to) | 345-349 |
| Number of pages | 5 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 215 |
| Issue number | 2 |
| State | Published - 1975 |
| Externally published | Yes |