Teratogenicity of bromocryptine in pregnant rats

D. Weinstein; D. Ben-Amitay; J. G. Schenker; A. Ornoy; A. A. Hochberg; R. Folman

doi:10.1007/BF02110676

Teratogenicity of bromocryptine in pregnant rats

D. Weinstein, D. Ben-Amitay, J. G. Schenker, A. Ornoy, A. A. Hochberg, R. Folman

Research output: Contribution to journal › Article › peer-review

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Abstract

The teratogenicity of bromocryptine (CB-154, Sandoz, Basel) was studied in three groups of pregnant rats which received 0.625 mg/kg/day, 1.25 mg/kg/day, and 2.5 mg/kg/day bromocryptine, respectively, i.m. and in a control group of pregnant rats which received the solvent only. There was no significant difference in the birth rate, fetal resorption rate, male/female ratio and malformation rate between the four groups. There was a significant elevation of the average fetal and placental weights between the experimental and the control fetuses. Bromocryptine does cross the placental barrier and in our study might act as growth promoting factor.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Archives of Gynecology
Volume	233
Issue number	1
DOIs	https://doi.org/10.1007/BF02110676
State	Published - Dec 1982
Externally published	Yes

Keywords

Bromocryptine
Rats
Teratogenicity

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title = "Teratogenicity of bromocryptine in pregnant rats",

abstract = "The teratogenicity of bromocryptine (CB-154, Sandoz, Basel) was studied in three groups of pregnant rats which received 0.625 mg/kg/day, 1.25 mg/kg/day, and 2.5 mg/kg/day bromocryptine, respectively, i.m. and in a control group of pregnant rats which received the solvent only. There was no significant difference in the birth rate, fetal resorption rate, male/female ratio and malformation rate between the four groups. There was a significant elevation of the average fetal and placental weights between the experimental and the control fetuses. Bromocryptine does cross the placental barrier and in our study might act as growth promoting factor.",

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year = "1982",

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AU - Weinstein, D.

AU - Ben-Amitay, D.

AU - Schenker, J. G.

AU - Ornoy, A.

AU - Hochberg, A. A.

AU - Folman, R.

PY - 1982/12

Y1 - 1982/12

N2 - The teratogenicity of bromocryptine (CB-154, Sandoz, Basel) was studied in three groups of pregnant rats which received 0.625 mg/kg/day, 1.25 mg/kg/day, and 2.5 mg/kg/day bromocryptine, respectively, i.m. and in a control group of pregnant rats which received the solvent only. There was no significant difference in the birth rate, fetal resorption rate, male/female ratio and malformation rate between the four groups. There was a significant elevation of the average fetal and placental weights between the experimental and the control fetuses. Bromocryptine does cross the placental barrier and in our study might act as growth promoting factor.

AB - The teratogenicity of bromocryptine (CB-154, Sandoz, Basel) was studied in three groups of pregnant rats which received 0.625 mg/kg/day, 1.25 mg/kg/day, and 2.5 mg/kg/day bromocryptine, respectively, i.m. and in a control group of pregnant rats which received the solvent only. There was no significant difference in the birth rate, fetal resorption rate, male/female ratio and malformation rate between the four groups. There was a significant elevation of the average fetal and placental weights between the experimental and the control fetuses. Bromocryptine does cross the placental barrier and in our study might act as growth promoting factor.

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KW - Rats

KW - Teratogenicity

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Teratogenicity of bromocryptine in pregnant rats

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