TY - JOUR
T1 - Taking drugs during pregnancy
T2 - How safe are the unsafe?
AU - Koren, G.
AU - Schuler, L.
PY - 2001
Y1 - 2001
N2 - QUESTION: I prescribed misoprostol to one of my patients with a peptic ulcer. When she found out she was pregnant while on the drug, both she and, admittedly, I were very scared to learn that the drug is teratogenic in that it causes Möbius syndrome. How great is the risk? ANSWER: Very small. Although women who use misoprostol during the first trimester have a 30-fold higher risk of having babies with Möbius syndrome, the malformation is so rare that, even if you see 1000 women who took misoprostol during embryogenesis, you might not see a single child with the syndrome. It is crucial to explain the size of the risk; otherwise women tend to believe the risk is huge even when, in fact, it is hardly measurable.
AB - QUESTION: I prescribed misoprostol to one of my patients with a peptic ulcer. When she found out she was pregnant while on the drug, both she and, admittedly, I were very scared to learn that the drug is teratogenic in that it causes Möbius syndrome. How great is the risk? ANSWER: Very small. Although women who use misoprostol during the first trimester have a 30-fold higher risk of having babies with Möbius syndrome, the malformation is so rare that, even if you see 1000 women who took misoprostol during embryogenesis, you might not see a single child with the syndrome. It is crucial to explain the size of the risk; otherwise women tend to believe the risk is huge even when, in fact, it is hardly measurable.
UR - http://www.scopus.com/inward/record.url?scp=0034975781&partnerID=8YFLogxK
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C2 - 11398725
AN - SCOPUS:0034975781
SN - 0008-350X
VL - 47
SP - 951+953
JO - Canadian Family Physician
JF - Canadian Family Physician
IS - MAY
ER -