Synthesis of model compounds for potential contrast agents containing phosphonate and peptide moieties

Hutti Shalem; Shimon Shatzmiller; Ben Ami Feit

doi:10.1039/a909086j

Synthesis of model compounds for potential contrast agents containing phosphonate and peptide moieties

Hutti Shalem, Shimon Shatzmiller, Ben Ami Feit

Department of Chemical Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The synthesis of dimethyl 2-acetoxy-2-(2,4-diiodo-5-aminophenyl)ethylphosphonate and dimethyl 2-acetoxy-2-(2,4,6-triiodo-3,5-diaminophenyl)ethylphosphonate is described. Several amido and peptidic derivatives of these two compounds were prepared. These products are composed of a combination of structural/functional moieties which pave the way for their potential application as non-ionic selective X-ray contrast agents.

Original language	English
Pages (from-to)	2831-2837
Number of pages	7
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	16
DOIs	https://doi.org/10.1039/a909086j
State	Published - 2000

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10.1039/a909086j

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AU - Shatzmiller, Shimon

AU - Feit, Ben Ami

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AB - The synthesis of dimethyl 2-acetoxy-2-(2,4-diiodo-5-aminophenyl)ethylphosphonate and dimethyl 2-acetoxy-2-(2,4,6-triiodo-3,5-diaminophenyl)ethylphosphonate is described. Several amido and peptidic derivatives of these two compounds were prepared. These products are composed of a combination of structural/functional moieties which pave the way for their potential application as non-ionic selective X-ray contrast agents.

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ER -

Synthesis of model compounds for potential contrast agents containing phosphonate and peptide moieties

Abstract

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