Synthesis of Gold Nanoparticle: Peptide–Drug Conjugates for Targeted Drug Delivery

K. Kalishwaralal, G. Luboshits, M. A. Firer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

15 Scopus citations

Abstract

Peptide–drug conjugates (PDCs) are being developed for the targeted delivery of drugs to cancer cells. Several approaches are being followed to enhance their stability in biological solutions. Here we describe an effective method to easily couple PDCs to polyethylene-coated gold nanoparticles. We also outline analytical methods to validate the coupling and assays to measure the stability and cytotoxic efficacy of the conjugates.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages145-154
Number of pages10
DOIs
StatePublished - 2020

Publication series

NameMethods in Molecular Biology
Volume2059
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Gold nanoparticles
  • Peptide–drug conjugates
  • Targeted drug delivery

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