TY - JOUR
T1 - Synthesis of axially chiral 1,8-diarylnaphthalene ligands and application in asymmetric catalysis
T2 - An intriguing fluorine effect
AU - Ghosh, Harisadhan
AU - Vavilala, Ravishashidhar
AU - Szpilman, Alex M.
N1 - Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.
PY - 2015/2/15
Y1 - 2015/2/15
N2 - A fluorinated and a non-fluorinated axially chiral 1,8-diarylnaphthalene ligand have been synthesized through an Ullmann and Suzuki coupling reaction based strategy. A practical methodology for the successful chiral resolution of the newly synthesized catechol based moiety is presented. We also disclose the preliminary application of these axially chiral molecules as ligands in asymmetric transformation reactions.
AB - A fluorinated and a non-fluorinated axially chiral 1,8-diarylnaphthalene ligand have been synthesized through an Ullmann and Suzuki coupling reaction based strategy. A practical methodology for the successful chiral resolution of the newly synthesized catechol based moiety is presented. We also disclose the preliminary application of these axially chiral molecules as ligands in asymmetric transformation reactions.
UR - http://www.scopus.com/inward/record.url?scp=84922188162&partnerID=8YFLogxK
U2 - 10.1016/j.tetasy.2014.12.008
DO - 10.1016/j.tetasy.2014.12.008
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AN - SCOPUS:84922188162
SN - 0957-4166
VL - 26
SP - 79
EP - 84
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 2-3
ER -