Synthesis of 35-deoxy amphotericin B methyl ester: A strategy for molecular editing

Alex M. Szpilman; Damiano M. Cereghetti; Nicholas R. Wurtz; Jeffrey M. Manthorpe; Erick M. Carreira

doi:10.1002/anie.200800589

Synthesis of 35-deoxy amphotericin B methyl ester: A strategy for molecular editing

Alex M. Szpilman, Damiano M. Cereghetti, Nicholas R. Wurtz, Jeffrey M. Manthorpe, Erick M. Carreira

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

(Chemical Presented) A modular strategy for the assembly of amphotericin B analogues with modifications in the macrolactone ring relies on the efficient gram-scale synthesis of all major and minor motifs of amphotericin B. Proof of concept has been achieved by the preparation of the 35-deoxy aglycone en route to the long-sought-after 35-deoxy analogue of amphotericin B.

Original language	English
Pages (from-to)	4335-4338
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	23
DOIs	https://doi.org/10.1002/anie.200800589
State	Published - 26 May 2008
Externally published	Yes

Keywords

Amphotericin B
Antifungal agents
Asymmetric synthesis
Natural products
Total synthesis

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10.1002/anie.200800589

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AU - Carreira, Erick M.

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Synthesis of 35-deoxy amphotericin B methyl ester: A strategy for molecular editing

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Keywords

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