Abstract
The synthesis of 2‐(Aminophenyl)‐2‐hydroxyethylphosphonates rac‐4a‐c is based on the formation of a hydroxyl function via addition of the lithium salt of dimethyl methylphosphonate (2) to aldehydes 1a‐c. The amino function in rac‐ 4a‐c is obtained by catalytic reduction of the nitro group in 3 at low pressure. The incorporation of the aminophosphonates rac‐4a‐c in short peptides, enables the formation of potential bioactive materials 12–14.
Original language | English |
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Pages (from-to) | 433-436 |
Number of pages | 4 |
Journal | Liebigs Annales |
Volume | 1995 |
Issue number | 2 |
DOIs | |
State | Published - 27 Jan 1995 |
Externally published | Yes |
Keywords
- Amines
- Aminophosphonates
- Nitro compounds
- Peptides
- Phosphonates