Synthesis and biological studies of 35-deoxy amphotericin B methyl ester

Alex M. Szpilman; Jeffrey M. Manthorpe; Erick M. Carreira

doi:10.1002/anie.200800590

Synthesis and biological studies of 35-deoxy amphotericin B methyl ester

Alex M. Szpilman, Jeffrey M. Manthorpe, Erick M. Carreira

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

(Chemical Presented) An indispensable OH group: The synthesis of 35-deoxy amphotericin B methyl ester was completed by using a novel method for the coupling of the mycosamine to the aglycone. The investigation of the antifungal activity and efflux-inducing ability of this compound provided data that underscore the relevance of the hydroxy group at C35 and supports the involvement of double-barrel ion channels.

Original language	English
Pages (from-to)	4339-4342
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	23
DOIs	https://doi.org/10.1002/anie.200800590
State	Published - 26 May 2008
Externally published	Yes

Keywords

Amphotericin B
Antifungal agents
Mechanism of action
Natural products
Total synthesis

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10.1002/anie.200800590

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KW - Mechanism of action

KW - Natural products

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Synthesis and biological studies of 35-deoxy amphotericin B methyl ester

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Keywords

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