Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

Bradley G. Wagner; Benjamin M. Althouse; Noga Givon-Lavi; Hao Hu; Ron Dagan

doi:10.1016/j.vaccine.2019.07.077

Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

Bradley G. Wagner, Benjamin M. Althouse, Noga Givon-Lavi, Hao Hu, Ron Dagan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35% (95% CI: 26, 44) and 19% (95% CI: 15, 24), respectively in Jewish and 70% (95% CI, 62, 77) and 41% (95% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.

Original language	English
Pages (from-to)	5625-5629
Number of pages	5
Journal	Vaccine
Volume	37
Issue number	37
DOIs	https://doi.org/10.1016/j.vaccine.2019.07.077
State	Published - 3 Sep 2019
Externally published	Yes

Keywords

Pneumococcal carriage
Pneumococcal conjugate vaccine
Streptococcus pneumoniae

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10.1016/j.vaccine.2019.07.077

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title = "Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era",

abstract = "Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35% (95% CI: 26, 44) and 19% (95% CI: 15, 24), respectively in Jewish and 70% (95% CI, 62, 77) and 41% (95% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.",

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AU - Hu, Hao

AU - Dagan, Ron

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AB - Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35% (95% CI: 26, 44) and 19% (95% CI: 15, 24), respectively in Jewish and 70% (95% CI, 62, 77) and 41% (95% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.

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Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

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