SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman; Frank K. Huynh; Reuven Gil; Yair Glick; Yael Shahar; Noga Touitou; Liat Nahum; Matan Y. Avivi; Asael Roichman; Yariv Kanfi; Asaf A. Gertler; Tirza Doniger; Olga R. Ilkayeva; Ifat Abramovich; Orly Yaron; Batia Lerrer; Eyal Gottlieb; Robert A. Harris; Doron Gerber; Matthew D. Hirschey; Haim Y. Cohen

doi:10.1016/j.celrep.2019.11.067

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman
, Frank K. Huynh
, Reuven Gil
, Yair Glick
, Yael Shahar
, Noga Touitou
, Liat Nahum
, Matan Y. Avivi
, Asael Roichman
, Yariv Kanfi
, Asaf A. Gertler
, Tirza Doniger
, Olga R. Ilkayeva
, Ifat Abramovich
, Orly Yaron
, Batia Lerrer
, Eyal Gottlieb
, Robert A. Harris
, Doron Gerber
, Matthew D. Hirschey

Haim Y. Cohen

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

Original language	English
Pages (from-to)	4127-4143.e8
Journal	Cell Reports
Volume	29
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2019.11.067
State	Published - 17 Dec 2019
Externally published	Yes

Keywords

PPARα
SIRT6
beta-oxidation
deacetylase
fasting
liver

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10.1016/j.celrep.2019.11.067

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Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., ... Cohen, H. Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports, 29(12), 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067

@article{2ee51ff8ff8d40ff96e784b510424ebe,

title = "SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα",

abstract = "How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.",

keywords = "PPARα, SIRT6, beta-oxidation, deacetylase, fasting, liver",

author = "Shoshana Naiman and Huynh, \{Frank K.\} and Reuven Gil and Yair Glick and Yael Shahar and Noga Touitou and Liat Nahum and Avivi, \{Matan Y.\} and Asael Roichman and Yariv Kanfi and Gertler, \{Asaf A.\} and Tirza Doniger and Ilkayeva, \{Olga R.\} and Ifat Abramovich and Orly Yaron and Batia Lerrer and Eyal Gottlieb and Harris, \{Robert A.\} and Doron Gerber and Hirschey, \{Matthew D.\} and Cohen, \{Haim Y.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

day = "17",

doi = "10.1016/j.celrep.2019.11.067",

language = "אנגלית",

volume = "29",

pages = "4127--4143.e8",

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Naiman, S, Huynh, FK, Gil, R, Glick, Y, Shahar, Y, Touitou, N, Nahum, L, Avivi, MY, Roichman, A, Kanfi, Y, Gertler, AA, Doniger, T, Ilkayeva, OR, Abramovich, I, Yaron, O, Lerrer, B, Gottlieb, E, Harris, RA, Gerber, D, Hirschey, MD & Cohen, HY 2019, 'SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα', Cell Reports, vol. 29, no. 12, pp. 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067

TY - JOUR

T1 - SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

AU - Naiman, Shoshana

AU - Huynh, Frank K.

AU - Gil, Reuven

AU - Glick, Yair

AU - Shahar, Yael

AU - Touitou, Noga

AU - Nahum, Liat

AU - Avivi, Matan Y.

AU - Roichman, Asael

AU - Kanfi, Yariv

AU - Gertler, Asaf A.

AU - Doniger, Tirza

AU - Ilkayeva, Olga R.

AU - Abramovich, Ifat

AU - Yaron, Orly

AU - Lerrer, Batia

AU - Gottlieb, Eyal

AU - Harris, Robert A.

AU - Gerber, Doron

AU - Hirschey, Matthew D.

AU - Cohen, Haim Y.

PY - 2019/12/17

Y1 - 2019/12/17

N2 - How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

AB - How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

KW - PPARα

KW - SIRT6

KW - beta-oxidation

KW - deacetylase

KW - fasting

KW - liver

UR - https://www.scopus.com/pages/publications/85076344864

U2 - 10.1016/j.celrep.2019.11.067

DO - 10.1016/j.celrep.2019.11.067

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C2 - 31851938

AN - SCOPUS:85076344864

SN - 2639-1856

VL - 29

SP - 4127-4143.e8

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

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Keywords

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