SIRT6, a protein with many faces

Asaf A. Gertler; Haim Y. Cohen

doi:10.1007/s10522-013-9478-8

SIRT6, a protein with many faces

Asaf A. Gertler, Haim Y. Cohen

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

Sirtuins are NAD⁺ dependent deacylases enzymes. There are seven mammalian sirtuins, SIRT1-SIRT7, which are localized to different cellular compartments and are capable of diverse catalytic activities. SIRT6 is a key regulator of healthy ageing. In the past decade our understanding of SIRT6 significantly increased in many different aspects. We know its cellular localization, catalytic activities, substrates and the pathways it is involved in. This review discusses the recent discoveries regarding the SIRT6 enzyme.

Original language	English
Pages (from-to)	629-639
Number of pages	11
Journal	Biogerontology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1007/s10522-013-9478-8
State	Published - Dec 2013
Externally published	Yes

Keywords

Ageing
Deacylation
SIRT6

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10.1007/s10522-013-9478-8

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title = "SIRT6, a protein with many faces",

abstract = "Sirtuins are NAD+ dependent deacylases enzymes. There are seven mammalian sirtuins, SIRT1-SIRT7, which are localized to different cellular compartments and are capable of diverse catalytic activities. SIRT6 is a key regulator of healthy ageing. In the past decade our understanding of SIRT6 significantly increased in many different aspects. We know its cellular localization, catalytic activities, substrates and the pathways it is involved in. This review discusses the recent discoveries regarding the SIRT6 enzyme.",

keywords = "Ageing, Deacylation, SIRT6",

author = "Gertler, {Asaf A.} and Cohen, {Haim Y.}",

note = "Funding Information: Acknowledgments We thank the members of Cohen{\textquoteright}s lab, in particular Shoshana Naiman, for their helpful comments on the manuscript. The research at Cohen{\textquoteright}s lab is supported by the Israel Science Foundation, Teva Pharmaceutical Industries LTD, I-Core Foundation, Israeli Ministry of Health, and the ERC: European Research Council.",

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SIRT6, a protein with many faces

Abstract

Keywords

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