Abstract
Captopril is an orally active inhibitor of angiotensin-converting enzyme. A rapid, accurate, and sensitive high-performance chromatography (HPLC) method is described for measuring plasma concentrations of captopril. Captopril was stabilized by forming an adduct with p-bromophenacyl bromide. This adduct was measured by HPLC using a C-18 reverse-phase column and monitoring the column effluent by ultraviolet absorption at 260 nm. The method proved to be linear in the clinical range of 10–1,000 ng/ml. The plasma levels of captopril in a young patient given a small oral dose were determined by this method.
| Original language | English |
|---|---|
| Pages (from-to) | 105-110 |
| Number of pages | 6 |
| Journal | Therapeutic Drug Monitoring |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1990 |
| Externally published | Yes |
Keywords
- Captopril
- DDPM
- High-performance liquid chromatography
- Ultraviolet detection
- ρ-bromophenacyl bromide
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