Short- and long-term outcomes of the titanium-NO stent registry

Morris Mosseri, Israel Tamari, Michael Plich, Yonathan Hasin, Mark Brizines, Aaron Frimerman, Hilton Miller, Jamal Jafari, Victor Guetta, Mivi Solomon, Chaim Lotan

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32 Scopus citations


Background: Five to 15% of the population have allergy to nickel, chromium, or molybdenum, which is a potential cause for in-stent restenosis. The Titan stent is made of stainless steel and is coated with titanium-nitride oxide (TiNOX), which completely prevents the discharge of metal elements. We performed a real-life multicenter registry to assess the short- and long-term characteristics of the Titan stent. Methods and results: A total of 103 Titan stents was implanted in 100 patients. Patients were 61.4±12.6 years old (81 men). Risk factors included hypercholesterolemia (63%), hypertension (53%), diabetes mellitus (DM; 35%), and current smoking (23%). Indications for PCI (percutaneous coronary intervention) were acute coronary syndromes (ACS) in 68% [acute ST elevation myocardial infarction (MI) in 8%], stable AP (angina pectoris) in 25%, and silent ischemia in 7% of the patients. Fifty-two percent of the treated lesions were of Type B2 or C. Lesion length was 14.3±2.9 mm and stent diameter was 3.06±0.36 mm. Indications for stenting were prevention of restenosis in 66%, residual stenosis in 33%, dissection in 13%, acute MI in 13%, and in-stent restenosis in 7% of the patients. Procedural success was 100%, with no complications. At 30 days, there were no major adverse cardiac events (MACE), including death, MI, and revascularization. At 180 days, only three patients had TVR (target vessel revascularization); two had TLR (target lesion revascularization) (one PCI and one CABG [coronary artery bypass grafting]), and one patient had a new narrowing proximal to the stent and underwent CABG due to multivessel disease. Conclusions: The Titan stent has a remarkable safety profile in high-risk patients and complex coronary lesions and excellent short- and long-term outcome with a very low clinical TLR rate.

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalCardiovascular Revascularization Medicine
Issue number1
StatePublished - Jan 2005
Externally publishedYes


  • Allergy
  • Angioplasty
  • Atherosclerosis
  • Coronary artery
  • Restenosis


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