TY - JOUR
T1 - Serum malondialdehyde and prevalent cardiovascular disease in hemodialysis
AU - Boaz, Mona
AU - Matas, Zipora
AU - Biro, Alexander
AU - Katzir, Ze'ev
AU - Green, Manfred
AU - Fainaru, Menahem
AU - Smetana, Shmuel
N1 - Funding Information:
This work was funded by Grant #4204 of the Chief Scientist's Office, Ministry of Health, Israel. The authors thank Ms. Emi Kalo and Ms. Larissa Shtendick, as well as the entire nursing staff, for their cooperation and dedication that contributed to the preparation of this work.
PY - 1999
Y1 - 1999
N2 - Background. Oxidative stress has been proposed as a mechanism by which the accelerated rate of cardiovascular disease (CVD) observed in maintenance hemodialysis (HD) patients may be explained. This study examined the effects of HD and CVD on serum malondialdehyde (MDA) levels as a marker of oxidative stress in HD patients with and without prevalent CVD. Serum MDA levels and CVD prevalence in HD were modeled. Methods. Serum MDA was determined using spectrophotometry in HD patients (N = 76, 53 men and 23 women, mean age 63.8 years) immediately prior to and at the conclusion of one midweek HD treatment. Traditional CVD risk factors, including serum lipids, lipoproteins, apolipoproteins, and fibrinogen, were also measured, as were serum chemistry and dialysis adequacy. Results. Mean serum MDA levels were significantly elevated in HD patients with prevalent CVD compared with those without, whereas serum lipoprotein and plasma fibrinogen levels did not differ between the two groups. Patients in the highest compared with the lowest tertile of postdialysis MDA were nearly four times as likely to have prevalent CVD, and serum MDA was the single strongest predictor of prevalent CVD in this patient population. Conclusions. These findings indicate the presence of oxidative stress in HD patients, and are consistent with the theory of oxidative stress as a factor in accelerated CVD in this population.
AB - Background. Oxidative stress has been proposed as a mechanism by which the accelerated rate of cardiovascular disease (CVD) observed in maintenance hemodialysis (HD) patients may be explained. This study examined the effects of HD and CVD on serum malondialdehyde (MDA) levels as a marker of oxidative stress in HD patients with and without prevalent CVD. Serum MDA levels and CVD prevalence in HD were modeled. Methods. Serum MDA was determined using spectrophotometry in HD patients (N = 76, 53 men and 23 women, mean age 63.8 years) immediately prior to and at the conclusion of one midweek HD treatment. Traditional CVD risk factors, including serum lipids, lipoproteins, apolipoproteins, and fibrinogen, were also measured, as were serum chemistry and dialysis adequacy. Results. Mean serum MDA levels were significantly elevated in HD patients with prevalent CVD compared with those without, whereas serum lipoprotein and plasma fibrinogen levels did not differ between the two groups. Patients in the highest compared with the lowest tertile of postdialysis MDA were nearly four times as likely to have prevalent CVD, and serum MDA was the single strongest predictor of prevalent CVD in this patient population. Conclusions. These findings indicate the presence of oxidative stress in HD patients, and are consistent with the theory of oxidative stress as a factor in accelerated CVD in this population.
KW - Atherosclerosis
KW - CVD
KW - Dialysis
KW - Lipid peroxidation
KW - Maintenance hemodialysis
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0032853944&partnerID=8YFLogxK
U2 - 10.1046/j.1523-1755.1999.00613.x
DO - 10.1046/j.1523-1755.1999.00613.x
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C2 - 10469377
AN - SCOPUS:0032853944
SN - 0085-2538
VL - 56
SP - 1078
EP - 1083
JO - Kidney International
JF - Kidney International
IS - 3
ER -