Seasonality and BDNF polymorphism influences depression outcome in patients with atopic dermatitis and psoriasis

Tatyana Vinnik, Michael Kirby, Maryia Bairachnaya, Igor Koman, Tatyana Tarkina, Gulnaz Sadykova, Gulshara Abildinova, Gulnara Batpenova, Albert Pinhasov

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objectives: To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission. Methods: Atopic dermatitis (AD, 56) and psoriasis (PS, 33) patients and healthy controls (HC, 49) were recruited over the 2014 calendar year. Patients were subdivided by immunoglobulin E (IgE) sensitivity (AD only), season and rs6265 genotype. Assessments were performed at onset and week 10 (Hamilton Depression Rating Scale [HAM-D], SCORAD/PASI, IgE, BDNF). Patients received standard corticosteroid and antihistamine interventions. Results: All patients responded to corticosteroid treatment. Seasonally differential outcomes were observed in all groups. HAM-D was elevated at onset and improved over 10 weeks: AD cohort 1 (autumn/winter, AD-1) patients improved and AD cohort 2 (spring/summer, AD-2) patients remained elevated. BDNF levels were elevated in AD and seasonal differential: AD-2 declined at 10 weeks, whereas AD-1 remained high (intrinsic AD) or elevated further (extrinsic AD). PS cohort 2 declined to below control at 10 weeks. AD Val/Val had persistently elevated HAM-D and AD Val/Met were either normal (AD-1) or persistently elevated (AD-2). Conclusions: Findings presented here suggest a strong influence of seasonality on depression outcome and BDNF expression in AD and PS and likely reflect separate patient populations which differentially respond to environment-based stressors.

Original languageEnglish
Pages (from-to)604-614
Number of pages11
JournalWorld Journal of Biological Psychiatry
Volume18
Issue number8
DOIs
StatePublished - 17 Nov 2017

Keywords

  • Atopic dermatitis
  • brain-derived neurotrophic factor
  • depression
  • psoriasis
  • seasonal variation

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