Schizophrenia and hallucinogen persisting perception disorder: A clinical investigation

Background and Objectives We compared characteristics of schizophrenia patients with prior LSD use who developed hallucinogen persisting perception disorder (SCH+HPPD) with those who did not (SCH-HPPD). Methods Data were collected for 37 subjects in the SCH+HPPD group and 43 subjects in the SCH-HPPD group. Results Socio-demographics and positive symptom scores were similar between groups. Individuals in the SCHIZO+HPPD group scored lower on general psychopathology and negative symptoms scores. Discussion and Conclusions Individuals with schizophrenia and HPPD present with less severe psychopathology, despite persistent perceptual disturbances. Scientific Significance Our findings highlight the importance of further research into this subset of patients.