Abstract
Mycosamine is a dideoxyaminosugar found in medicinally relevant macrolides, including amphotericin B and nystatin. Herein we report a reliable, high yielding, scalable synthesis of a mycosamine donor. A major goal of our approach was to minimize purifications via judicious selection of protecting groups; the inherent properties of the allose framework created some deprotection obstacles that were ultimately solved.
Original language | English |
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Article number | C06505SS |
Pages (from-to) | 3380-3388 |
Number of pages | 9 |
Journal | Synthesis |
Issue number | 19 |
DOIs | |
State | Published - 1 Dec 2005 |
Externally published | Yes |
Keywords
- Asymmetric synthesis
- Glycosylations
- Medicinal chemistry
- Natural products
- Protecting groups