TY - JOUR
T1 - Safety of inhaled corticosteroids delivered by plastic and metal spacers
AU - Amirav, I.
AU - Mansour, Y.
AU - Tiosano, T.
AU - Chamny, S.
AU - Chirurg, S.
AU - Oren, S.
AU - Grossman, Z.
AU - Kahana, L.
AU - Kahan, E.
AU - Newhouse, M. T.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Background: Because of its non-electrostatic properties the metal Nebuchamber (NC) valved holding chamber (VHC) delivers a greater mass of aerosol to the mouth than the polypropylene Aerochamber (AC) VHC. Delivery of more aerosol to the lungs may also increase systemic absorption of inhaled corticosteroids (ICS) and hypothalamo-pituitary-adrenal (HPA) suppression. Methods: Thirty children (mean 4.3 (SD 0.3) years) received 200 μg budesonide twice daily by NC or AC, both with the mask provided, in a randomised, two month crossover trial. Twenty four hour urinary free cortisol (UFC) was determined as a measure of HPA suppression. Results: UFC decreased from 42.3 (7.8) nmol UFC/nmol creatinine control to 26.2 (2.4) (p = 0.06 v control) after AC, and to 24.5 (2.5) (p = 0.04 v control) after NC (p = 0.4 AC v NC). Conclusions: Despite a greater total dose delivered to the mouth, NC is not associated with greater HPA suppression when using 400 μg/day budesonide under real life conditions in young children.
AB - Background: Because of its non-electrostatic properties the metal Nebuchamber (NC) valved holding chamber (VHC) delivers a greater mass of aerosol to the mouth than the polypropylene Aerochamber (AC) VHC. Delivery of more aerosol to the lungs may also increase systemic absorption of inhaled corticosteroids (ICS) and hypothalamo-pituitary-adrenal (HPA) suppression. Methods: Thirty children (mean 4.3 (SD 0.3) years) received 200 μg budesonide twice daily by NC or AC, both with the mask provided, in a randomised, two month crossover trial. Twenty four hour urinary free cortisol (UFC) was determined as a measure of HPA suppression. Results: UFC decreased from 42.3 (7.8) nmol UFC/nmol creatinine control to 26.2 (2.4) (p = 0.06 v control) after AC, and to 24.5 (2.5) (p = 0.04 v control) after NC (p = 0.4 AC v NC). Conclusions: Despite a greater total dose delivered to the mouth, NC is not associated with greater HPA suppression when using 400 μg/day budesonide under real life conditions in young children.
UR - http://www.scopus.com/inward/record.url?scp=0038359140&partnerID=8YFLogxK
U2 - 10.1136/adc.88.6.527
DO - 10.1136/adc.88.6.527
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C2 - 12765924
AN - SCOPUS:0038359140
SN - 0003-9888
VL - 88
SP - 527
EP - 528
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
IS - 6
ER -