TY - JOUR
T1 - Safety of first trimester exposure to histamine H2 blockers. A prospective cohort study
AU - Magee, Laura A.
AU - Inocencion, Gilda
AU - Kamboj, Laveena
AU - Rosetti, Frances
AU - Koren, Gideon
PY - 1996
Y1 - 1996
N2 - The objective of this study was to examine whether H2 blockers represent a major teratogenic risk. This prospective cohort study was done at the Motherisk Program, a Teratology Information Service, Toronto, Canada. The subjects included 178 women who contacted Motherisk about gestational H2-blocker use, and 178 controls matched for maternal age, smoking, and heavy alcohol consumption. The main outcome measures were primary - major malformations, and secondary - pregnancy outcome, method of delivery, gestational age, prematurity, birthweight, small for gestational age infants, neonatal health problems, and developmental milestones. No increase in major malformations was found following first trimester exposure to H2 blockers [2.1% vs 3.5% (controls), mean difference (95% CI) -1.4% (-5.2, +2.4)]. No other aspects of pregnancy outcome or neonatal health differed between groups. This study suggests that H2-blocker exposure during the first trimester does not represent a major teratogenic risk.
AB - The objective of this study was to examine whether H2 blockers represent a major teratogenic risk. This prospective cohort study was done at the Motherisk Program, a Teratology Information Service, Toronto, Canada. The subjects included 178 women who contacted Motherisk about gestational H2-blocker use, and 178 controls matched for maternal age, smoking, and heavy alcohol consumption. The main outcome measures were primary - major malformations, and secondary - pregnancy outcome, method of delivery, gestational age, prematurity, birthweight, small for gestational age infants, neonatal health problems, and developmental milestones. No increase in major malformations was found following first trimester exposure to H2 blockers [2.1% vs 3.5% (controls), mean difference (95% CI) -1.4% (-5.2, +2.4)]. No other aspects of pregnancy outcome or neonatal health differed between groups. This study suggests that H2-blocker exposure during the first trimester does not represent a major teratogenic risk.
KW - Drug-induced abnormalities
KW - Histamine H-receptor antagonist
KW - Pregnancy complications
UR - http://www.scopus.com/inward/record.url?scp=0029681354&partnerID=8YFLogxK
U2 - 10.1007/BF02088230
DO - 10.1007/BF02088230
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C2 - 8654145
AN - SCOPUS:0029681354
SN - 0163-2116
VL - 41
SP - 1145
EP - 1149
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 6
ER -