TY - JOUR
T1 - Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O- specific polysaccharide conjugates in children
AU - Ashkenazi, Shai
AU - Passwell, Justen H.
AU - Harlev, Efrat
AU - Miron, Dan
AU - Dagan, Ron
AU - Farzan, Nahid
AU - Ramon, Reut
AU - Majadly, Fathy
AU - Bryla, Dolores A.
AU - Karpas, Arthur B.
AU - Robbins, John B.
AU - Schneerson, Rachel
PY - 1999
Y1 - 1999
N2 - O-specific polysaccharide conjugates of shigellae were safe and immunogenic in young adults, and a Shigella sonnei conjugate conferred protection [1-3]. Shigellosis is primarily a disease of children; therefore, the safety and immunogenicity of S. sonnei and Shigella flexneri 2a conjugates were studied in 4- to 7-year-old children. Local and systemic reactions were minimal. The first injection of both conjugates elicited significant rises in geometric mean levels of serum IgG only to the homologous lipopolysaccharide (LPS) (S. sonnei, 0.32-8.25 ELISA units [EU]; S. flexneri 2a, 1.15-20.5 EU; P < .0001). Revaccination at 6 weeks induced a booster response to S. flexneri 2a LPS (20.5-30.5 EU, P = .003). Six months later, the geometric mean levels of IgG anti-LPS for both groups were higher than the prevaccination levels (P < .0001). Similar, but lesser, rises were observed for IgM and IgA anti-LPS. The investigational Shigella conjugates were safe and immunogenic in children and merit evaluation of their efficacy.
AB - O-specific polysaccharide conjugates of shigellae were safe and immunogenic in young adults, and a Shigella sonnei conjugate conferred protection [1-3]. Shigellosis is primarily a disease of children; therefore, the safety and immunogenicity of S. sonnei and Shigella flexneri 2a conjugates were studied in 4- to 7-year-old children. Local and systemic reactions were minimal. The first injection of both conjugates elicited significant rises in geometric mean levels of serum IgG only to the homologous lipopolysaccharide (LPS) (S. sonnei, 0.32-8.25 ELISA units [EU]; S. flexneri 2a, 1.15-20.5 EU; P < .0001). Revaccination at 6 weeks induced a booster response to S. flexneri 2a LPS (20.5-30.5 EU, P = .003). Six months later, the geometric mean levels of IgG anti-LPS for both groups were higher than the prevaccination levels (P < .0001). Similar, but lesser, rises were observed for IgM and IgA anti-LPS. The investigational Shigella conjugates were safe and immunogenic in children and merit evaluation of their efficacy.
UR - http://www.scopus.com/inward/record.url?scp=0033064593&partnerID=8YFLogxK
U2 - 10.1086/314759
DO - 10.1086/314759
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 10228084
AN - SCOPUS:0033064593
SN - 0022-1899
VL - 179
SP - 1565
EP - 1568
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -