Rituximab monotherapy as interim therapy in precursor B-ALL adults during peroids of hepatic toxicity: Report of two cases

Maya Koren-Michowitz; Naomi Rahimi-Levene; Yulia Volcheck; Izhar Hardan; Abraham Kornberg

doi:10.1002/ajh.20675

Rituximab monotherapy as interim therapy in precursor B-ALL adults during peroids of hepatic toxicity: Report of two cases

Maya Koren-Michowitz, Naomi Rahimi-Levene, Yulia Volcheck, Izhar Hardan, Abraham Kornberg

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Precursor B-ALL blasts may be positive for CD20 in up to 50% of cases. There are few reports on the use of the anti CD20 monoclonal antibody, rituximab, in children with B-ALL. We report on two adult patients with precursor B-ALL who developed significant hepatic toxicity during induction chemotherapy. Single agent rituximab was given until recovery of liver enzymes was established. Both patients were able to continue further chemotherapy, underwent an Allo BMT and are now 10-12 months after diagnosis in a continuous CR.

Original language	English
Pages (from-to)	979-980
Number of pages	2
Journal	American Journal of Hematology
Volume	81
Issue number	12
DOIs	https://doi.org/10.1002/ajh.20675
State	Published - Dec 2006
Externally published	Yes

Keywords

Hepatic toxicity
Precursor B-ALL
Rituximab

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10.1002/ajh.20675

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Rituximab monotherapy as interim therapy in precursor B-ALL adults during peroids of hepatic toxicity: Report of two cases

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