Rhabdomyolysis and Acute Renal Failure Induced by Paraphenylenediamine

Z. Averbukh, D. Modai, Y. Leonov, J. Weissgarten, G. Lewinsohn, L. Fucs, A. Golik, E. Rosenmann

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


1 We present a 40-year-old healthy man who developed a typical clinical picture of rhabdomyolysis following the administration of paraphenylenediamine by a witchdoctor as a pain killer. 2 Two groups of 15 mice were given paraphenylenediamine 70 mg/kg and 35 mg/kg respectively. Biochemical and histological findings of rhabdomyolysis developed in both groups, without kidney damage. 3 Paraphenylenediamine may cause rhabdomyolysis resulting in acute renal failure in humans. In mice, however, it produces rhabdomyolysis, but the kidneys are not affected.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalHuman and Experimental Toxicology
Issue number5
StatePublished - Sep 1989
Externally publishedYes


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