Resistance to TOP-1 Inhibitors: Good Old Drugs Still Can Surprise Us

Keyphrases

• Anticancer Drugs 25%
• Binding Site 25%
• Clinical Outcomes 25%
• Cytotoxic Effect 25%
• DNA Breaks 25%
• DNA Cleavage 25%
• DNA Complex 25%
• DNA Strands 25%
• DNA Topoisomerase 25%
• Irinotecan 100%
• Irinotecan Resistance 50%
• Ligation 25%
• Major Resistance 25%
• Metabolism 25%
• Old Drugs 100%
• Overcoming Resistance 25%
• Recent Advancements 25%
• Resistance Mechanisms 50%
• Secondary Resistance 25%
• SN-38 25%
• Strategies to Overcome 25%
• Target DNA 25%
• Therapeutic Strategies 25%
• Topoisomerase 75%
• Valuable Insight 25%

Biochemistry, Genetics and Molecular Biology

• Anticancer 25%
• Binding Site 25%
• Cytotoxicity 25%
• DNA Cleavage 25%
• DNA Strand 25%
• DNA Topoisomerase 100%
• Metabolic Pathway 25%
• Topoisomerase 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Anticarcinogen 16%
• Binding Site 16%
• Cytotoxicity 16%
• DNA Topoisomerase 66%
• Elimination 16%
• Irinotecan 100%