Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime

Zmira Samra; Haim Shmuely; Yaron Niv; Gabriel Dinari; Douglas J. Passaro; Alex Geler; Eyal Gal; Michal Fishman; Jacklin Bachor; Jacob Yahav

doi:10.1093/jac/dkf041

Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime

Zmira Samra, Haim Shmuely, Yaron Niv, Gabriel Dinari, Douglas J. Passaro, Alex Geler, Eyal Gal, Michal Fishman, Jacklin Bachor, Jacob Yahav

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Abstract

The resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime was tested in 138 isolates, including 28 from treatment failures. No resistance to tetracycline was detected. Resistance to amoxicillin was found in one isolate (MIC = 1.5 mg/L) from an untreated patient, and resistance to cefixime in two isolates from each group (P = 0.18). Resistance to metronidazole and clarithromycin was much higher in the isolates from treated than from untreated patients: 60.7% and 38.2% for metronidazole (MIC ≥ 8 mg/L) (P = 0.03); 46.4% and 8.2% for clarithromycin (MIC ≥ 2 mg/L) (P < 0.001). Therapeutic outcome would benefit from susceptibility testing, especially after treatment failure.

Original language	English
Pages (from-to)	1023-1026
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	49
Issue number	6
DOIs	https://doi.org/10.1093/jac/dkf041
State	Published - 2002
Externally published	Yes

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title = "Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime",

abstract = "The resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime was tested in 138 isolates, including 28 from treatment failures. No resistance to tetracycline was detected. Resistance to amoxicillin was found in one isolate (MIC = 1.5 mg/L) from an untreated patient, and resistance to cefixime in two isolates from each group (P = 0.18). Resistance to metronidazole and clarithromycin was much higher in the isolates from treated than from untreated patients: 60.7% and 38.2% for metronidazole (MIC ≥ 8 mg/L) (P = 0.03); 46.4% and 8.2% for clarithromycin (MIC ≥ 2 mg/L) (P < 0.001). Therapeutic outcome would benefit from susceptibility testing, especially after treatment failure.",

author = "Zmira Samra and Haim Shmuely and Yaron Niv and Gabriel Dinari and Passaro, {Douglas J.} and Alex Geler and Eyal Gal and Michal Fishman and Jacklin Bachor and Jacob Yahav",

year = "2002",

doi = "10.1093/jac/dkf041",

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AU - Samra, Zmira

AU - Shmuely, Haim

AU - Niv, Yaron

AU - Dinari, Gabriel

AU - Passaro, Douglas J.

AU - Geler, Alex

AU - Gal, Eyal

AU - Fishman, Michal

AU - Bachor, Jacklin

AU - Yahav, Jacob

PY - 2002

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AB - The resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime was tested in 138 isolates, including 28 from treatment failures. No resistance to tetracycline was detected. Resistance to amoxicillin was found in one isolate (MIC = 1.5 mg/L) from an untreated patient, and resistance to cefixime in two isolates from each group (P = 0.18). Resistance to metronidazole and clarithromycin was much higher in the isolates from treated than from untreated patients: 60.7% and 38.2% for metronidazole (MIC ≥ 8 mg/L) (P = 0.03); 46.4% and 8.2% for clarithromycin (MIC ≥ 2 mg/L) (P < 0.001). Therapeutic outcome would benefit from susceptibility testing, especially after treatment failure.

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Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime

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