Abstract
Cis-diamminedichloroplatinum (II) (cisplatin CDDP) is an extremely potent chemotherapeutic agent. Its efficacy, however, is hindered by the cumulative dose-dependent nephrotoxicity which can lead to permanent renal impairment. The mechanisms of the renal transport of cisplatin are not clear. As a first step towards understanding the renal handling of cisplatin we studied its renal clearance in dogs, as well as the effects of organic anion and cation administration on cisplatin. Our results document net tubular secretion of cisplatin. Both an organic anion (probenecid) and cations (quinidine, cimetidine, ranitidine) significantly decreased renal clearance of free CDDP without affecting GFR.
| Original language | English |
|---|---|
| Pages (from-to) | 388-394 |
| Number of pages | 7 |
| Journal | Clinical and Investigative Medicine |
| Volume | 14 |
| Issue number | 5 |
| State | Published - 1991 |
| Externally published | Yes |
Keywords
- cisplatin
- clearance
- organic anions
- organic cations