Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients

G. Zalsman; G. M. Anderson; M. Peskin; A. Frisch; R. A. King; M. Vekslerchik; E. Sommerfeld; E. Michaelovsky; L. Sher; A. Weizman; A. Apter

doi:10.1007/s00702-004-0244-6

Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients

G. Zalsman, G. M. Anderson, M. Peskin, A. Frisch, R. A. King, M. Vekslerchik, E. Sommerfeld, E. Michaelovsky, L. Sher, A. Weizman, A. Apter

Department of Psychology

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38 Scopus citations

Abstract

Relationships between the serotonin transporter promoter polymorphism (5-HTTLPR), platelet serotonin transporter (SERT) binding and clinical phenotype were examined in 32 suicidal and 28 non-suicidal Ashkenazi Israeli adolescent psychiatric inpatients. The 5-HTTLPR polymorphism was not associated with transporter binding or with suicidality or other clinical phenotypes. However, in the suicidal group, a significant positive correlation between platelet SERT density and anger scores (n = 32, r = .40; p = .027) and a negative correlation between platelet count and trait anxiety (n = 32, r = -.42; p = .034) were observed.

Original language	English
Pages (from-to)	309-315
Number of pages	7
Journal	Journal of Neural Transmission
Volume	112
Issue number	2
DOIs	https://doi.org/10.1007/s00702-004-0244-6
State	Published - Feb 2005

Keywords

5-HTTLPR
Adolescent
Endophenotype
Serotonin
Serotonin transporter
Suicide

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10.1007/s00702-004-0244-6

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Zalsman, G., Anderson, G. M., Peskin, M., Frisch, A., King, R. A., Vekslerchik, M., Sommerfeld, E., Michaelovsky, E., Sher, L., Weizman, A., & Apter, A. (2005). Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients. Journal of Neural Transmission, 112(2), 309-315. https://doi.org/10.1007/s00702-004-0244-6

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abstract = "Relationships between the serotonin transporter promoter polymorphism (5-HTTLPR), platelet serotonin transporter (SERT) binding and clinical phenotype were examined in 32 suicidal and 28 non-suicidal Ashkenazi Israeli adolescent psychiatric inpatients. The 5-HTTLPR polymorphism was not associated with transporter binding or with suicidality or other clinical phenotypes. However, in the suicidal group, a significant positive correlation between platelet SERT density and anger scores (n = 32, r = .40; p = .027) and a negative correlation between platelet count and trait anxiety (n = 32, r = -.42; p = .034) were observed.",

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author = "G. Zalsman and Anderson, {G. M.} and M. Peskin and A. Frisch and King, {R. A.} and M. Vekslerchik and E. Sommerfeld and E. Michaelovsky and L. Sher and A. Weizman and A. Apter",

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Zalsman, G, Anderson, GM, Peskin, M, Frisch, A, King, RA, Vekslerchik, M, Sommerfeld, E, Michaelovsky, E, Sher, L, Weizman, A & Apter, A 2005, 'Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients', Journal of Neural Transmission, vol. 112, no. 2, pp. 309-315. https://doi.org/10.1007/s00702-004-0244-6

Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients. / Zalsman, G.; Anderson, G. M.; Peskin, M. et al.
In: Journal of Neural Transmission, Vol. 112, No. 2, 02.2005, p. 309-315.

Research output: Contribution to journal › Article › peer-review

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AU - Zalsman, G.

AU - Anderson, G. M.

AU - Peskin, M.

AU - Frisch, A.

AU - King, R. A.

AU - Vekslerchik, M.

AU - Sommerfeld, E.

AU - Michaelovsky, E.

AU - Sher, L.

AU - Weizman, A.

AU - Apter, A.

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AB - Relationships between the serotonin transporter promoter polymorphism (5-HTTLPR), platelet serotonin transporter (SERT) binding and clinical phenotype were examined in 32 suicidal and 28 non-suicidal Ashkenazi Israeli adolescent psychiatric inpatients. The 5-HTTLPR polymorphism was not associated with transporter binding or with suicidality or other clinical phenotypes. However, in the suicidal group, a significant positive correlation between platelet SERT density and anger scores (n = 32, r = .40; p = .027) and a negative correlation between platelet count and trait anxiety (n = 32, r = -.42; p = .034) were observed.

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KW - Endophenotype

KW - Serotonin

KW - Serotonin transporter

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Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients

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