Re-enter the syn -(Me,I)Bimane: A Gateway to Bimane Derivatives with Extended π-Systems

Oleg Szumski, Joy Karmakar, Flavio Grynszpan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

syn -α-Diiodobimane (syn -(R 2,I)B) is a key intermediate for the derivatization of the bimane core in the α-positions. Here we describe an expeditious method to prepare symmetric α-bimane derivatives, such as syn -(R 2,I)B, as well as unsymmetric ones. Our strategy turns the synthesis of α derivatives with extended π-systems practical and affordable. We applied this approach to the synthesis of ethynylbenzaldehyde bearing bimanes as potential selective probes for aldolase class I enzymes.

Original languageEnglish
Pages (from-to)1141-1145
Number of pages5
JournalSynlett
Volume32
Issue number11
DOIs
StatePublished - 1 Jul 2021

Keywords

  • bimane
  • derivatives
  • fluorescence
  • intermediate
  • iodobimane

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