Quantitative genetics of circulating Hyaluronic Acid (HA) and its correlation with hand osteoarthritis and obesity-related phenotypes in a community-based sample

Jai Prakash, Gulzhan Gabdulina, Svetlana Trofimov, Gregory Livshits

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: One of the potential molecular biomarkers of osteoarthritis (OA) is hyaluronic acid (HA). HA levels may be related to the severity and progression of OA. However, little is known about the contribution of major risk factors for osteoarthritis, e.g. obesity-related phenotypes and genetics to HA variation. Aim: To clarify the quantitative effect of these factors on HA. Subjects and methods: An ethnically homogeneous sample of 911 apparently healthy European-derived individuals, assessed for radiographic hand osteoarthritis (RHOA), HA, leptin, adiponectin, and several anthropometrical measures of obesity-related phenotypes was studied. Model-based quantitative genetic analysis was used to reveal genetic and shared environmental factors affecting the variation of the study’s phenotypes. Results: The HA levels significantly correlated with the age, RHOA, adiponectin, obesity-related phenotypes, and the waist-to-hip ratio. The putative genetic effects contributed significantly to the variation of HA (66.2 ± 9.3%) and they were also significant factors in the variations of all the other studied phenotypes, with the heritability estimate ranging between 0.122 ± 4.4% (WHR) and 45.7 ± 2.2% (joint space narrowing). Conclusions: This is the first study to report heritability estimates of HA variation and its correlation with obesity-related phenotypes, ADP and RHOA. However, the nature of genetic effects on HA and its correlation with other study phenotypes require further clarification.

Original languageEnglish
Pages (from-to)522-530
Number of pages9
JournalAnnals of Human Biology
Volume44
Issue number6
DOIs
StatePublished - 18 Aug 2017
Externally publishedYes

Keywords

  • HA
  • Kellgren-Lawrence
  • additive genetics
  • adiponectin
  • fat mass
  • heritability
  • joint space narrowing
  • leptin
  • sarcopenic index

Fingerprint

Dive into the research topics of 'Quantitative genetics of circulating Hyaluronic Acid (HA) and its correlation with hand osteoarthritis and obesity-related phenotypes in a community-based sample'. Together they form a unique fingerprint.

Cite this