Abstract
Objectives: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results: A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants’ perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
| Original language | English |
|---|---|
| Pages (from-to) | 284-292 |
| Number of pages | 9 |
| Journal | BJU International |
| Volume | 123 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2019 |
Keywords
- #pcsm
- #ProstateCancer
- BRCA1
- BRCA2
- psychosocial
- quality of life
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In: BJU International, Vol. 123, No. 2, 02.2019, p. 284-292.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations
AU - Bancroft, Elizabeth
AU - Saya, Sibel
AU - Page, Elizabeth
AU - Myhill, Kathryn
AU - Thomas, Sarah
AU - Pope, Jennifer
AU - Chamberlain, Anthony
AU - Hart, Rachel
AU - Glover, Wayne
AU - Cook, Jackie
AU - Rosario, Derek
AU - Helfand, Brian T.
AU - Selkirk, Christina Hutten
AU - Davidson, Rosemarie
AU - Longmuir, Mark
AU - Eccles, Diana
AU - Gadea, Neus
AU - Brewer, Carole
AU - Barwell, Julian
AU - Salinas, Monica
AU - Greenhalgh, Lynn
AU - Tischkowitz, Marc
AU - Henderson, Alex
AU - Evans, David Gareth
AU - Buys, Saundra
AU - Eeles, Rosalind
AU - Aaronson, Neil K.
AU - Eeles, Rosalind
AU - Bancroft, Elizabeth
AU - Page, Elizabeth
AU - Kote-Jarai, Zsofia
AU - Ardern-Jones, Audrey
AU - Bangma, Chris
AU - Castro, Elena
AU - Dearnaley, David
AU - Falconer, Alison
AU - Foster, Christopher
AU - Gronberg, Henrik
AU - Hamdy, Freddie C.
AU - Johannsson, Oskar Thor
AU - Khoo, Vincent
AU - Eccles, Diana
AU - Lilja, Hans
AU - Evans, D. Gareth
AU - Eyfjord, Jorunn
AU - Lubinski, Jan
AU - Maehle, Lovise
AU - Mikropoulos, Christos
AU - Millner, Alan
AU - Mitra, Anita
AU - Offman, Judith
AU - Moynihan, Clare
AU - Rennert, Gad
AU - Suri, Mohnish
AU - Dias, Alex
AU - Taylor, Natalie
AU - D'Mello, Lucia
AU - Pope, Jenny
AU - James, Paul
AU - Mitchell, Gillian
AU - Shanley, Sue
AU - Richardson, Kate
AU - McKinley, Joanne
AU - Petelin, Lara
AU - Murphy, Morgan
AU - Mascarenhas, Lyon
AU - Murphy, Declan
AU - Lam, Jimmy
AU - Taylor, Louise
AU - Miller, Cathy
AU - Stapleton, Alan
AU - Chong, Michael
AU - Suthers, Graeme
AU - Poplawski, Nicola
AU - Tucker, Katherine
AU - Andrews, Lesley
AU - Duffy, Jessica
AU - Millard, Richard
AU - Ward, Robyn
AU - Williams, Rachel
AU - Stricker, Phillip
AU - Kirk, Judy
AU - Bowman, Michelle
AU - Patel, Manish
AU - Harris, Marion
AU - O'Connell, Shona
AU - Hunt, Clare
AU - Smyth, Courtney
AU - Frydenberg, Mark
AU - Lindeman, Geoffrey
AU - Shackleton, Kylie
AU - Morton, Catherine
AU - Susman, Rachel
AU - McGaughran, Julie
AU - Boon, Melanie
AU - Pachter, Nicholas
AU - Townshend, Sharron
AU - Schofield, Lyn
AU - Nicholls, Cassandra
AU - Spigelman, Allan
AU - Gleeson, Margaret
AU - Amor, David
AU - Burke, Jo
AU - Patterson, Briony
AU - Swindle, Peter
AU - Scott, Rodney
AU - Foulkes, William
AU - Boshari, Talia
AU - Aprikian, Armen
AU - Jensen, Thomas
AU - Bojeson, Anders
AU - Osther, Palle
AU - Skytte, Anne-Bine
AU - Cruger, Dorthe
AU - Tondering, Majbritt Kure
AU - Gerdes, Anne-Marie
AU - Schmutzler, Rita
AU - Rhiem, Kerstin
AU - Wihler, Petra
AU - Kast, K.
AU - Griebsch, C.
AU - Johannsson, Oskar
AU - Stefansdottir, Vigdis
AU - Murthy, Vedang
AU - Sarin, Rajiv
AU - Awatagiri, Kasturi
AU - Ghonge, Sujata
AU - Kowtal, Pradnya
AU - Mulgund, Gouri
AU - Gallagher, David
AU - Bambury, Richard
AU - Farrell, Michael
AU - Gallagher, Fergal
AU - Kiernan, Ingrid
AU - Friedman, Eitan
AU - Chen-Shtoyerman, Rakefet
AU - Basevitch, Alon
AU - Leibovici, Dan
AU - Melzer, Ehud
AU - Ben-Yehoshua, Sagi Josefsberg
AU - Nicolai, Nicola
AU - Radice, Paolo
AU - Valdagni, Riccardo
AU - Magnani, Tiziana
AU - Gay, Simona
AU - Teo, Soo Hwang
AU - Tan, Hui Meng
AU - Yoon, Sook-Yee
AU - Thong, Meow Keong
AU - Vasen, Hans
AU - Ringleberg, Janneke
AU - van Asperen, Christi
AU - Kiemeney, Bart
AU - van Zelst-Stams, Wendy
AU - Ausems, Margreet G. E. M.
AU - van der Luijt, Rob B.
AU - van Os, Theo
AU - Ruijs, Marielle W. G.
AU - Adank, Muriel A.
AU - Oldenburg, Rogier A.
AU - Helderman-van den Enden, A. Paula T. J. M.
AU - Caanen, B. A. H.
AU - Oosterwijk, Jan C.
AU - Moller, Pal
AU - Brennhovd, Bjorn
AU - Medvik, Heidi
AU - Hanslien, Eldbjorg
AU - Grindedal, Eli Marie
AU - Cybulski, Cezary
AU - Wokolorczyk, Dominika
AU - Teixeira, Manuel
AU - Maia, Sofia
AU - Peixoto, Ana
AU - Henrique, Rui
AU - Oliveira, Jorge
AU - Goncalves, Nuno
AU - Araujo, Luis
AU - Seixas, Manuela
AU - Souto, Joao Paulo
AU - Nogueira, Pedro
AU - Copakova, Lucia
AU - Zgajnar, Janez
AU - Krajc, Mateja
AU - Vrecar, Alenka
AU - Capella, Gabriel
AU - Ramon y Cajal, Teresa
AU - Fisas, David
AU - Mora, Josefina
AU - Esquena, Salvador
AU - Balmana, Judith
AU - Morote, Juan
AU - Liljegren, Annelie
AU - Hjalm-Eriksson, Marie
AU - Ekdahl, Karl-Johan
AU - Carlsson, Stefan
AU - George, Angela
AU - Kemp, Zoe
AU - Wiggins, Jennifer
AU - Moss, Cathryn
AU - Van As, Nicholas
AU - Thompson, Alan
AU - Ogden, Chris
AU - Woodhouse, Christopher
AU - Kumar, Pardeep
AU - Evans, D. Gareth
AU - Bulman, Barbara
AU - Rothwell, Jeanette
AU - Tricker, Karen
AU - Wise, Gillian
AU - Mercer, Catherine
AU - McBride, Donna
AU - Costello, Philandra
AU - Pearce, Allison
AU - Torokwa, Audrey
AU - Paterson, Joan
AU - Clowes, Virginia
AU - Taylor, Amy
AU - Newcombe, Barbara
AU - Walker, Lisa
AU - Halliday, Dorothy
AU - Stayner, Barbara
AU - Fleming-Brown, D.
AU - Snape, Katie
AU - Hanson, Helen
AU - Hodgson, Shirley
AU - Brice, Glen
AU - Homfray, Tessa
AU - Hammond, Carrie
AU - Kohut, Kelly
AU - Anjum, Uruj
AU - Dearing, Audrey
AU - Mencias, Mark
AU - Potter, Alison
AU - Renton, Caroline
AU - Searle, Anne
AU - Hill, Kathryn
AU - Goodman, Selina
AU - Garcia, Lynda
AU - Devlin, Gemma
AU - Everest, Sarah
AU - Nadolski, Maria
AU - Douglas, Fiona
AU - Jobson, Irene
AU - Paez, Edgar
AU - Donaldson, Alan
AU - Tomkins, Sue
AU - Langman, Caroline
AU - Jacobs, Chris
AU - Pichert, Gabriella
AU - Shaw, Adam
AU - Kulkarni, Anju
AU - Tripathi, Vishakha
AU - Rose, Sarah
AU - Compton, Cecilia
AU - Watson, Michelle
AU - Reinholtz, Cherylin
AU - Brady, Angela
AU - Dorkins, Huw
AU - Melville, Athalie
AU - Kosicka-Slawinska, Monika
AU - Cummings, Carole
AU - Kiesel, Vicki
AU - Bartlett, Marion
AU - Randhawa, Kashmir
AU - Ellery, Natalie
AU - Side, Lucy
AU - Male, Alison
AU - Simon, Kate
AU - Rees, Katie
AU - Tidey, Lizzie
AU - Gurasashvili, Jana
AU - Nevitt, Louise
AU - Ingram, Stuart
AU - Howell, Alice
AU - Rosario, Derek
AU - Catto, James
AU - Howson, Joanne
AU - Ong, Kai-Ren
AU - Chapman, Cyril
AU - Cole, Trevor
AU - Heaton, Tricia
AU - Hoffman, Jonathan
AU - Burgess, Lucy
AU - Huber, Camilla
AU - Islam, Farah
AU - Watt, Cathy
AU - Duncan, Alexis
AU - Kockelbergh, Roger
AU - Mzazi, Shumikazi
AU - Dineen, Amy
AU - Sattar, Ayisha
AU - Kaemba, Beckie
AU - Sidat, Zahirah
AU - Patel, Nafisa
AU - Siguake, Kas
AU - Birt, Angela
AU - Poultney, Una
AU - Umez-Eronini, Nkem
AU - Mom, Jaswant
AU - Sutton, Vivienne
AU - Cornford, Philip
AU - Bermingham, Nicola
AU - Yesildag, Pembe
AU - Treherne, Katy
AU - Griffiths, Julie
AU - Cogley, Lyn
AU - Gott, Hannah
AU - Rubinstein, Wendy S.
AU - Hulick, Peter
AU - McGuire, Michael
AU - Shevrin, Daniel
AU - Kaul, Karen
AU - Weissman, Scott
AU - Newlin, Anna
AU - Vogel, Kristen
AU - Weiss, Shelly
AU - Hook, Nicole
AU - Buys, Saundra
AU - Goldgar, David
AU - Conner, Tom
AU - Venne, Vickie
AU - Stephenson, Robert
AU - Dechet, Christopher
AU - Domchek, Susan
AU - Powers, Jacquelyn
AU - Rustgi, Neil
AU - Strom, Sara
AU - Arun, Banu
AU - Davis, John W.
AU - Yamamura, Yuko
AU - Obeid, Elias
AU - Giri, Veda
AU - Gross, Laura
AU - Bealin, Lisa
AU - Cooney, Kathy
AU - Stoffel, Elena
AU - Okoth, Linda
N1 - Publisher Copyright: © 2018 The Authors BJU International published by John Wiley & Sons Ltd on behalf of BJU International
PY - 2019/2
Y1 - 2019/2
N2 - Objectives: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results: A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants’ perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
AB - Objectives: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results: A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants’ perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
KW - #pcsm
KW - #ProstateCancer
KW - BRCA1
KW - BRCA2
KW - psychosocial
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85060125537&partnerID=8YFLogxK
U2 - 10.1111/bju.14412
DO - 10.1111/bju.14412
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
SN - 1464-4096
VL - 123
SP - 284
EP - 292
JO - BJU International
JF - BJU International
IS - 2
ER -