@article{fdced7a18d9b4144ac634c78e48e75be,
title = "PROSTAGLANDINS AS FIRST MEDIATORS OF STRESS?",
author = "Israel Hanukoglu",
note = "Funding Information: dins handicaps have never been study proposed for this role. prostaglan- The first mediator of stress should (1) be producible in and secreted from any tissue affected by a stressor, (2) be carried in blood, and (3) stimulate corticotrophin release (A.C.T.H.).{\textquoteright} 3 Since prostaglandins can be produced in a wide variety of tis- sues,4and are secreted during tissue inflammation{\textquoteright} and treat- ment with noxious stimuli,6 and since some prostaglandins stimulate A.c.T.H. release at the level of the hypothalamus and anterior pituitary,e some prostaglandins could be the first mediators of stress. This hypothesis could be tested by measurement of A.C.T.H. secretion in response to a stressor in animals given prostaglandin-synthesis inhibitors. I thank Prof. Hans Selye and Sari R. Gilman for their criticisms and the Ford Foundation (630-0505A), the N.I.M.H. (MH2132), and the University of Wisconsin-Madison for financial support.",
year = "1977",
month = jan,
day = "22",
doi = "10.1016/S0140-6736(77)91787-1",
language = "אנגלית",
volume = "309",
pages = "193",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier B.V.",
number = "8004",
}