Prostaglandins as First Mediators of Stress

Israel Hanukoglu

Research output: Contribution to journalLetterpeer-review

17 Scopus citations


To the Editor: Recently, I advanced the hypothesis that some prostaglandins may be the first mediators of stress1 as defined by Selye within the framework of his stress theory.23 This hypothesis was based on an integration of the observations that prostaglandins, like the hypothetical first mediators of stress, can be released from any tissue in response to noxious stimuli4 and can stimulate corticotropin release.5 6 7 After this hypothesis was published I discovered that the experiments suggested as a test of this hypothesis had been performed and reported in two abstracts by Hedge and Thompson and Thompson and Hedge.89 The findings. No extract is available for articles shorter than 400 words.

Original languageEnglish
Pages (from-to)1414
Number of pages1
JournalNew England Journal of Medicine
Issue number24
StatePublished - 16 Jun 1977
Externally publishedYes


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