TY - JOUR
T1 - Prostaglandins as First Mediators of Stress
AU - Hanukoglu, Israel
N1 - Funding Information:
dins handicaps have never been study proposed for this role. prostaglan- The first mediator of stress should (1) be producible in and secreted from any tissue affected by a stressor, (2) be carried in blood, and (3) stimulate corticotrophin release (A.C.T.H.).’ 3 Since prostaglandins can be produced in a wide variety of tis- sues,4and are secreted during tissue inflammation’ and treat- ment with noxious stimuli,6 and since some prostaglandins stimulate A.c.T.H. release at the level of the hypothalamus and anterior pituitary,e some prostaglandins could be the first mediators of stress. This hypothesis could be tested by measurement of A.C.T.H. secretion in response to a stressor in animals given prostaglandin-synthesis inhibitors. I thank Prof. Hans Selye and Sari R. Gilman for their criticisms and the Ford Foundation (630-0505A), the N.I.M.H. (MH2132), and the University of Wisconsin-Madison for financial support.
PY - 1977/6/16
Y1 - 1977/6/16
N2 - To the Editor: Recently, I advanced the hypothesis that some prostaglandins may be the first mediators of stress1 as defined by Selye within the framework of his stress theory.23 This hypothesis was based on an integration of the observations that prostaglandins, like the hypothetical first mediators of stress, can be released from any tissue in response to noxious stimuli4 and can stimulate corticotropin release.5 6 7 After this hypothesis was published I discovered that the experiments suggested as a test of this hypothesis had been performed and reported in two abstracts by Hedge and Thompson and Thompson and Hedge.89 The findings. No extract is available for articles shorter than 400 words.
AB - To the Editor: Recently, I advanced the hypothesis that some prostaglandins may be the first mediators of stress1 as defined by Selye within the framework of his stress theory.23 This hypothesis was based on an integration of the observations that prostaglandins, like the hypothetical first mediators of stress, can be released from any tissue in response to noxious stimuli4 and can stimulate corticotropin release.5 6 7 After this hypothesis was published I discovered that the experiments suggested as a test of this hypothesis had been performed and reported in two abstracts by Hedge and Thompson and Thompson and Hedge.89 The findings. No extract is available for articles shorter than 400 words.
UR - http://www.scopus.com/inward/record.url?scp=0017373554&partnerID=8YFLogxK
U2 - 10.1056/NEJM197706162962420
DO - 10.1056/NEJM197706162962420
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C2 - 859553
AN - SCOPUS:0017373554
SN - 0028-4793
VL - 296
SP - 1414
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 24
ER -