Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial

Rhobert W. Evans; Ofer Shpilberg; B. Jessica Shaten; Shabnam Ali; M. Ilyas Kamboh; Lewis H. Kuller

doi:10.1016/S0895-4356(00)00260-2

Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial

Rhobert W. Evans, Ofer Shpilberg, B. Jessica Shaten, Shabnam Ali, M. Ilyas Kamboh, Lewis H. Kuller

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In this nested case-control study, lipoprotein (a) [Lp(a)] concentrations and apo(a) isoform size were measured in serum samples obtained from men participating in the prospective Multiple Risk Factor Intervention Trial (MRFIT). Serum from men aged 35 to 57 years and stored for up to 20 years were analyzed for Lp(a) levels (n=736) and isoform size (n=487), respectively. Cases involved nonfatal myocardial infarctions (MI; n=98), documented during the active phase of the study that ended on February 28, 1982 and coronary heart disease (CHD) deaths (n=148) monitored through 1990. Median Lp(a) levels did not differ between cases and controls and mean apo(a) size did not vary between cases and controls in the entire study population. When adjusted for age and Lp(a) concentration, logistic regression analysis indicated that small apo(a) isoforms were associated with CHD deaths among smokers (OR 3.31; 95% CI 1.07-10.28).

Original language	English
Pages (from-to)	51-57
Number of pages	7
Journal	Journal of Clinical Epidemiology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/S0895-4356(00)00260-2
State	Published - 2001
Externally published	Yes

Keywords

Cardiovascular disease
Isoform
Lipoprotein(a)
MRFIT
Prospective

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10.1016/S0895-4356(00)00260-2

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title = "Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial",

abstract = "In this nested case-control study, lipoprotein (a) [Lp(a)] concentrations and apo(a) isoform size were measured in serum samples obtained from men participating in the prospective Multiple Risk Factor Intervention Trial (MRFIT). Serum from men aged 35 to 57 years and stored for up to 20 years were analyzed for Lp(a) levels (n=736) and isoform size (n=487), respectively. Cases involved nonfatal myocardial infarctions (MI; n=98), documented during the active phase of the study that ended on February 28, 1982 and coronary heart disease (CHD) deaths (n=148) monitored through 1990. Median Lp(a) levels did not differ between cases and controls and mean apo(a) size did not vary between cases and controls in the entire study population. When adjusted for age and Lp(a) concentration, logistic regression analysis indicated that small apo(a) isoforms were associated with CHD deaths among smokers (OR 3.31; 95% CI 1.07-10.28).",

keywords = "Cardiovascular disease, Isoform, Lipoprotein(a), MRFIT, Prospective",

author = "Evans, {Rhobert W.} and Ofer Shpilberg and Shaten, {B. Jessica} and Shabnam Ali and Kamboh, {M. Ilyas} and Kuller, {Lewis H.}",

note = "Funding Information: We thank Ms. B. Hauth for expert technical assistance. The mortality follow-up, storage of sera and data analysis for this report were supported by research grant R01-HL-43232 from the National Institutes of Health, Bethesda, MD. The study was partly supported by NIH grants HL44672, HL49074 and HL52611 to M.I.K. ",

year = "2001",

doi = "10.1016/S0895-4356(00)00260-2",

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volume = "54",

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AU - Evans, Rhobert W.

AU - Shpilberg, Ofer

AU - Shaten, B. Jessica

AU - Ali, Shabnam

AU - Kamboh, M. Ilyas

AU - Kuller, Lewis H.

N1 - Funding Information: We thank Ms. B. Hauth for expert technical assistance. The mortality follow-up, storage of sera and data analysis for this report were supported by research grant R01-HL-43232 from the National Institutes of Health, Bethesda, MD. The study was partly supported by NIH grants HL44672, HL49074 and HL52611 to M.I.K.

PY - 2001

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N2 - In this nested case-control study, lipoprotein (a) [Lp(a)] concentrations and apo(a) isoform size were measured in serum samples obtained from men participating in the prospective Multiple Risk Factor Intervention Trial (MRFIT). Serum from men aged 35 to 57 years and stored for up to 20 years were analyzed for Lp(a) levels (n=736) and isoform size (n=487), respectively. Cases involved nonfatal myocardial infarctions (MI; n=98), documented during the active phase of the study that ended on February 28, 1982 and coronary heart disease (CHD) deaths (n=148) monitored through 1990. Median Lp(a) levels did not differ between cases and controls and mean apo(a) size did not vary between cases and controls in the entire study population. When adjusted for age and Lp(a) concentration, logistic regression analysis indicated that small apo(a) isoforms were associated with CHD deaths among smokers (OR 3.31; 95% CI 1.07-10.28).

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Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial

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