Prolonged exposure to angiotensin-converting enzyme inhibitors during pregnancy. Fetal toxicity could be reversible

A. Shrim, H. Berger, J. Kingdom, A. Hamoudi, P. S. Shah, G. Koren

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Question: I read in a Motherisk Update that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during pregnancy. Many women, however, do not know they are pregnant for quite some time after conception. One of my patients was taking ACE inhibitors for 3 to 4 months while she was pregnant. How should I advise her? Answer: The deleterious effects ACE inhibitors have on fetuses were seen only after exposure during the second and third trimesters and were mostly secondary to renal damage. These effects can be reversed, as described in this Motherisk Update.

Original languageEnglish
Pages (from-to)1335-1337
Number of pages3
JournalCanadian Family Physician
Volume51
Issue numberOCT.
StatePublished - Oct 2005
Externally publishedYes

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