Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clones in Myeloproliferative Neoplasm Patients: A Cross-Sectional Study

Odit Gutwein; Yoav Englander; Katrin Herzog-Tzarfati; Talia Filipovich-Rimon; Arie Apel; Ronit Marcus; Naomi Rahimi-Levene; Maya Koren-Michowitz

doi:10.1016/j.clml.2019.07.441

Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clones in Myeloproliferative Neoplasm Patients: A Cross-Sectional Study

Odit Gutwein
, Yoav Englander
, Katrin Herzog-Tzarfati
, Talia Filipovich-Rimon
, Arie Apel
, Ronit Marcus
, Naomi Rahimi-Levene
, Maya Koren-Michowitz

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) and myeloproliferative neoplasm (MPN) are diseases associated with increased thrombosis. PNH clones are commonly found in other hematologic diseases, such as myelodysplastic syndromes and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.

Original language	English
Pages (from-to)	812-814
Number of pages	3
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/j.clml.2019.07.441
State	Published - Dec 2019
Externally published	Yes

Keywords

Clones
JAK2 V617F
MPN
PNH

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10.1016/j.clml.2019.07.441

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title = "Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clones in Myeloproliferative Neoplasm Patients: A Cross-Sectional Study",

abstract = "Paroxysmal nocturnal hemoglobinuria (PNH) and myeloproliferative neoplasm (MPN) are diseases associated with increased thrombosis. PNH clones are commonly found in other hematologic diseases, such as myelodysplastic syndromes and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2\% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.",

keywords = "Clones, JAK2 V617F, MPN, PNH",

author = "Odit Gutwein and Yoav Englander and Katrin Herzog-Tzarfati and Talia Filipovich-Rimon and Arie Apel and Ronit Marcus and Naomi Rahimi-Levene and Maya Koren-Michowitz",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.clml.2019.07.441",

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T1 - Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clones in Myeloproliferative Neoplasm Patients

T2 - A Cross-Sectional Study

AU - Gutwein, Odit

AU - Englander, Yoav

AU - Herzog-Tzarfati, Katrin

AU - Filipovich-Rimon, Talia

AU - Apel, Arie

AU - Marcus, Ronit

AU - Rahimi-Levene, Naomi

AU - Koren-Michowitz, Maya

PY - 2019/12

Y1 - 2019/12

N2 - Paroxysmal nocturnal hemoglobinuria (PNH) and myeloproliferative neoplasm (MPN) are diseases associated with increased thrombosis. PNH clones are commonly found in other hematologic diseases, such as myelodysplastic syndromes and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.

AB - Paroxysmal nocturnal hemoglobinuria (PNH) and myeloproliferative neoplasm (MPN) are diseases associated with increased thrombosis. PNH clones are commonly found in other hematologic diseases, such as myelodysplastic syndromes and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.

KW - Clones

KW - JAK2 V617F

KW - MPN

KW - PNH

UR - https://www.scopus.com/pages/publications/85072999616

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JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

IS - 12

ER -

Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clones in Myeloproliferative Neoplasm Patients: A Cross-Sectional Study

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Keywords

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