Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clones in Myeloproliferative Neoplasm Patients: A Cross-Sectional Study

Odit Gutwein, Yoav Englander, Katrin Herzog-Tzarfati, Talia Filipovich-Rimon, Arie Apel, Ronit Marcus, Naomi Rahimi-Levene, Maya Koren-Michowitz

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) and myeloproliferative neoplasm (MPN) are diseases associated with increased thrombosis. PNH clones are commonly found in other hematologic diseases, such as myelodysplastic syndromes and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.

Original languageEnglish
Pages (from-to)812-814
Number of pages3
JournalClinical Lymphoma, Myeloma and Leukemia
Volume19
Issue number12
DOIs
StatePublished - Dec 2019
Externally publishedYes

Keywords

  • Clones
  • JAK2 V617F
  • MPN
  • PNH

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