Prenatal exposure to misoprostol and vascular disruption defects: A case-control study

F. R. Vargas, L. Schuler-Faccini, D. Brunoni, C. Kim, V. F.A. Meloni, S. M.M. Sugayama, L. Albano, J. C. Llerena, J. C.C. Almeida, A. Duarte, D. P. Cavalcanti, E. Goloni-Bertollo, A. Conte, G. Koren, A. Addis

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101 Scopus citations

Abstract

Prenatal exposure to misoprostol has been associated with Moebius and limb defects. Vascular disruption has been proposed as the mechanism for these teratogenic effects. The present study is a multicenter, casecontrol study that was designed to compare the frequency of prenatal misoprostol use between mothers of Brazilian children diagnosed with vascular disruption defects and matched control mothers of children diagnosed with other types of defects. A total of 93 cases and 279 controls were recruited in eight participating centers. Prenatal exposure was identified in 32 infants diagnosed with vascular disruption defects (34.4%) compared with only 12 (4.3%) in the control group (P < 0.0000001). Our data suggest that prenatal exposure to misoprostol is associated to the occurrence of vascular disruption defects in the newborns. 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)302-306
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume95
Issue number4
DOIs
StatePublished - 11 Dec 2000
Externally publishedYes

Keywords

  • Limb defect
  • Misoprostol
  • Moebius sequence
  • Vascular disruption

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