TY - JOUR
T1 - Pregnancy-associated listeriosis
T2 - Clinical characteristics and geospatial analysis of a 10-year period in Israel
AU - for the Israeli Listeria Study Group
AU - Elinav, Hila
AU - Hershko-Klement, Anat
AU - Valinsky, Lea
AU - Jaffe, Josef
AU - Wiseman, Anat
AU - Shimon, Hila
AU - Braun, Eyal
AU - Paitan, Yossi
AU - Block, Colin
AU - Sorek, Rotem
AU - Nir-Paz, Ran
AU - Miron, D.
AU - Glikman, Danny
AU - Soboh, S.
AU - Nseir, W.
AU - Paz, A.
AU - Cohen, E.
AU - Mendelson, B.
AU - Paz, E.
AU - Shimoni, Z.
AU - Wattad, M.
AU - Ravid, M.
AU - Keller, N.
AU - Rahav, G.
AU - Dan, M.
AU - Shechner, V.
AU - Weinberger, M.
AU - Nadir, E.
AU - Troshin, T.
AU - Riesenberg, K.
AU - Tsabari, A.
AU - Lachish, T.
AU - Halperin, E.
AU - Anis, E.
AU - Vasiliev, V.
AU - Japeth, R.
N1 - Publisher Copyright:
© The Author 2014.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background. Listeria monocytogenes is a foodborne pathogen that causes life-threatening infections in elderly, immunocompromised, and pregnant women. In pregnancy it may cause fetal loss or a preterm delivery, and the neonate is prone to neonatal sepsis and death. Methods. We created a cohort of all L. monocytogenes cases during 10 years (1998-2007) in Israel, by a comprehensive review of cases in hospitals throughout the country and cases reported to the Ministry of Health. Results. One hundred sixty-six pregnancy-related listeriosis cases were identified, resulting in a yearly incidence of 5-25 cases per 100 000 births. Presentation associated with fetal demise was more common in the second trimester (55.3%), and preterm labor (52.3%) and abnormal fetal heart rate monitoring (22.2%) were more common in the third trimester (P = .001). Fetal viability was low in the second trimester (29.2%) and much higher (95.3%) in the third trimester. Each additional week of pregnancy increased the survival chance by 33% (odds ratio, 1.331 [95% confidence interval, 1.189-1.489]). A single case of maternal mortality was identified. Listeria monocytogenes serotype 4b was more common in pregnancy-related than in non-pregnancy-related cases (79.5% vs 61.3%, P = .011). Pulsed-field gel electrophoresis analysis suggested that 1 pulsotype is responsible for 35.7% of the pregnancy cases between 2001 and 2007. This clone is closely related to the Italian gastroenteritis-associated HPB2262 and the invasive US Scott A L. monocytogenes strains. Conclusions. Our survey emphasizes the high rate of pregnancy-related listeriosis in Israel and shows that specific clones might account for this.
AB - Background. Listeria monocytogenes is a foodborne pathogen that causes life-threatening infections in elderly, immunocompromised, and pregnant women. In pregnancy it may cause fetal loss or a preterm delivery, and the neonate is prone to neonatal sepsis and death. Methods. We created a cohort of all L. monocytogenes cases during 10 years (1998-2007) in Israel, by a comprehensive review of cases in hospitals throughout the country and cases reported to the Ministry of Health. Results. One hundred sixty-six pregnancy-related listeriosis cases were identified, resulting in a yearly incidence of 5-25 cases per 100 000 births. Presentation associated with fetal demise was more common in the second trimester (55.3%), and preterm labor (52.3%) and abnormal fetal heart rate monitoring (22.2%) were more common in the third trimester (P = .001). Fetal viability was low in the second trimester (29.2%) and much higher (95.3%) in the third trimester. Each additional week of pregnancy increased the survival chance by 33% (odds ratio, 1.331 [95% confidence interval, 1.189-1.489]). A single case of maternal mortality was identified. Listeria monocytogenes serotype 4b was more common in pregnancy-related than in non-pregnancy-related cases (79.5% vs 61.3%, P = .011). Pulsed-field gel electrophoresis analysis suggested that 1 pulsotype is responsible for 35.7% of the pregnancy cases between 2001 and 2007. This clone is closely related to the Italian gastroenteritis-associated HPB2262 and the invasive US Scott A L. monocytogenes strains. Conclusions. Our survey emphasizes the high rate of pregnancy-related listeriosis in Israel and shows that specific clones might account for this.
KW - Listeria monocytogenes
KW - Listeriosis
KW - Pregnancy-related infections
UR - http://www.scopus.com/inward/record.url?scp=84929939328&partnerID=8YFLogxK
U2 - 10.1093/cid/ciu504
DO - 10.1093/cid/ciu504
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C2 - 24973315
AN - SCOPUS:84929939328
SN - 1058-4838
VL - 59
SP - 953
EP - 961
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 7
ER -